Tom Holland as Nathan Drake

Mark Wahlberg as Victor 'Sully' Sullivan

Sophia Ali as Chloe Frazer

Tati Gabrielle as Jo Braddock

Antonio Banderas as Santiago Moncada

Steven Waddington as The Scotsman

Rudy Pankow as Young Sam

Tiernan Jones as Young Nate

Pingi Moli as Hugo

Jesús Evita as Guard at Museum

Georgia Goodman as Sister Bernadette

Diarmaid Murtagh as Police Officer

Joseph Balderrama as Carlos

Serena Posadino as Goldie

Alana Boden as Zoe

Jonathan Failla as Unsuspecting Doorman

Anthony Thomas as Luxury Sedan Driver

Peter Seaton-Clark as Auctioneer

Robert Maaser as Guard at Auction

Eskindir Tesfay as Security Guard

Manuel de Blas as Armando Moncada

Carme Capdet as Spanish Nun

Julia Schunevitsch as Club Bartender #1

Alois Knapps as Club Bartender #2

Patricia Meeden as Spanish Woman in Club

Nolan North as Hotel Guest

Matt Barkley as Hotel Bellman

Jimmy Hart as Concepcion Helo Pilot

Brett Praed as Concepcion Co-Pilot

Carlo Kitzlinger as Trinidad Helo PIlot

Pilou Asbæk as Gage

Rubén Doblas Gundersen as Young Man (uncredited)