Matthew McConaughey as Dirk Pitt

Penélope Cruz as Dr. Eva Rojas

Steve Zahn as Al Giordino

Lennie James as General Zateb Kazim

Lambert Wilson as Yves Massarde

William H. Macy as Admiral Jim Sandecker

Rainn Wilson as Rudi Gunn

Glynn Turman as Dr. Frank Hopper

Jude Akuwudike as Imam

Clint Dyer as Oshodi

Delroy Lindo as Carl

Robert Cavanah as Captain Tombs

Paulin Fodouop as Modibo

Abdul Salis as Oumar

Maurice Lee as Zakara

Tosin Sanyalo as Azikiwe Nwokolo

Rakie Ayola as Mrs. Nwokolo

Patrick Malahide as Ambassador Polidori

Emmanuel Ighodaro as Kazim's Officer Asselar

Mark Aspinall as Lawyer

Christopher Bello as Train Driver

Nicholas Beveney as Gunboat 1 Officer

Empotoe Bosage as Pick Up Truck Guard

Matthew Flynn as 1st Lieutenant, Ironclad

Ouahbou Houcine as Tuareg Village Boy #1

Daniel Njo Lobé as Tuareg Sangare

Francis Magee as Fuse Cutter

Thierno Amath Mbaye as Pick Up Truck Driver

Femi Ogunbanjo as Modibo's Tuareg #2

Eddie Osei as Train Guard

Nathan Osgood as Gun Captain

Lahcen Ouezgane as Tuareg Village Boy #2

Robert Paterson as NUMA Crew Member

Christopher Saul as Pilot, Ironclad

Billy Seymour as Powder Monkey

Mark Springer as Solar Plant Guard

Celestine Vita as Old Woman in Labbezanga

Mark Wells as Sailor Who Drops Gold