Adrien Brody as Henry Barthes

Marcia Gay Harden as Principal Carol Dearden

James Caan as Mr. Charles Seaboldt

Christina Hendricks as Ms. Sarah Madison

Lucy Liu as Dr. Doris Parker

Blythe Danner as Ms. Perkins

Tim Blake Nelson as Mr. Wiatt

William Petersen as Mr. 'Sarge' Kepler

Bryan Cranston as Mr. Dearden

Sami Gayle as Erica

Betty Kaye as Meredith

Louis Zorich as Grampa

Isiah Whitlock, Jr. as Mr. Mathias

Chris Papavasiliou as Dr. Hart

Kwoade Cross as Andy

David Hausen as Angry Dad

Roslyn Ruff as Angry Mother

Jerry Walsh as Cafeteria Worker

John Cenatiempo as Male Child Services Worker

Brenda Pressley as Female Child Services Worker

Tiffani Holland as Cindy

Lucian Maisel as David

Alex Boniello as Dennis

Celia Au as Ellen

Mary Joy as Female Orderly

Michael Hammond as Frank

Ronen Rubinstein as Gangsta

Al Calderon as George

Brennan Brown as Greg Raymond

Celia Schaefer as Gretchen from the Free Clinic

Reagan Leonard as Patricia Barthes

Tarikk Mudu as Jerry

Kevin T. Collins as John in Apartment

Stephen Payne as John on Bus

James Hosey as Kenny

Michael Kaufman as Kid in Henry's Class

Nancy Rodriguez as Lupe

Justin Campbell as Male Orderly

Aaron Sauter as Marcus

Josh Pais as Meredith's Father

Renée Felice Smith as Missy

Doug E. Doug as Mr. Norris

Rebecka Ray as Mrs. Wiatt

Patricia Rae as Ms. Estrada

Mama Kohn as Prep Club Girl #1

Corwin C. Tuggles as Ricky

Lonon Jay Wilson as School Cop

Samantha Logan as Spitting Daughter

Ralph Rodriguez as Student #23

Annabel Barrett as Student #4

April Maxey as Tanya

Amber Vanterpool as Tina

Eli Massillon as Tony

Alsharik Sejour as Tutored Kid

Jonathan Hudson as Wiatt's Son

Elvis Muccino as Young Henry