Bette Midler as Jacqueline Susann

Nathan Lane as Irving Mansfield

Stockard Channing as Florence Maybelle

David Hyde Pierce as Michael Hastings

John Cleese as Henry Marcus

John Larroquette as Maury Manning

Amanda Peet as Debbie

Dina Spybey-Waters as Bambi Madison

Paul Benedict as Prof. Brainiac

Jeff Ross as Shecky

David Costabile as Junior Editor

Frank Vincent as Aristotle Onassis

Ricky Mabe as Guy at 14

Christopher McDonald as Brad Bradburn

Robin Wilcock as Stage murderer

Terrence Labrosse as Radio Actor

Pauline Little as Leslie Barnett

William Hill as Passerby

Mal Z. Lawrence as Mort

Adam Heller as Howie

Ellen David as Sylvia

Dan Ziskie as Guy's Doctor

Anna Lobell as Receptionist

Brett Gillen as Man With Bicycle

Olga Merediz as Mrs. Ramirez

Jacklin Webb as Nurse

Clebert Ford as Claude

Sonia Benezra as Manicurist

Richard Litt as Buddy

Maurice Carlton as Orderly #1

Edward B. Goldstein as Eddie in Lindy's

Larry Block as Herbie

Jack Eagle as Waiter

Le Clanché du Rand as Lissy Hastings

Elizabeth Lawrence as Missy Hastings

Helen Stenborg as Aunt Abigail

John Cunningham as Nelson Hastings

Charles S. Doucet as Teamster

John Sanford Moore as Bob Shawcross

Richard McConomy as Harry Gladrey

Lisa Bronwyn Moore as Irma Gladrey

Steven McCarthy as Book Nook Clerk

James Villemaire as Jim Morrison

Karyn Quackenbush as TV Cook

Sam Street as Truman Capote