Michael J. Fox as Stuart Little (voice)

Chazz Palminteri as Smokey (voice)

Nathan Lane as Snowbell (voice)

Geena Davis as Mrs. Little

Hugh Laurie as Mr. Little

Jonathan Lipnicki as George Little

David Alan Grier as Red (voice)

Steve Zahn as Monty (voice)

Jim Doughan as Lucky / Officer Allen (voice)

Bruno Kirby as Mr. Stout (voice)

Jennifer Tilly as Mrs. Stout (voice)

Stan Freberg as Race Announcer (voice)

Jeffrey Jones as Uncle Crenshaw

Connie Ray as Aunt Tina

Allyce Beasley as Aunt Beatrice

Brian Doyle-Murray as Cousin Edgar

Estelle Getty as Grandma Estelle

Harold Gould as Grandpa Spencer

Patrick Thomas O'Brien as Uncle Stretch

Julia Sweeney as Mrs. Keeper

Dabney Coleman as Dr. Beechwood

Miles Marsico as Anton

Jon Polito as Officer Sherman

Joe Bays as Race Starter

Taylor Negron as Salesman

Kimmy Robertson as Race Spectator

Tannis Benedict as Hot Dog Vendor

Chuck Blechen as Skipper

Westleigh M. Styer as Skipper

Larry Goodhue as Boat Registrar

Joshua Paule as New Yorker (uncredited)