Sylvester Stallone as John Rambo

Julie Benz as Sarah

Matthew Marsden as School Boy

Graham McTavish as Lewis

Reynaldo Gallegos as Diaz

Tim Kang as En-Joo

Jake La Botz as Reese

Maung Maung Khin as Tint

Paul Schulze as Michael Burnett

Cameron Pearson as Jeff

Thomas Peterson as Dentist

Tony Skarberg as Videographer

James With as Preacher

Kasikorn Niyompattana as Snake Hunter #2

Shaliew 'Lek' Bamrungbun as Snake Hunter #1

Suppakorn Kitsuwan as Myint

Aung Aay Noi as Lt. Aye

Ken Howard as Arthur Marsh

Aung Theng as Pirate Leader

Pornpop 'Tor' Kampusiri as Snake Village Owner

Wasawat Panyarat as Snake Village MC

Kammul Kawtep as Snake Village Young Charmer

Sornram Patchimtasanakarn as Tha

Noa 'Arunee Prijareonsuk' Jei as Karen Interpreter

Kjam Saen as Karen Interpreter #2

Aun Lung Su as Burmese Hut Guard #1

Pan Dokngam as Burmese Hut Guard #2

Han Pik as Burmese Hut Guard #3

Tip Tiya as Burmese Gate Guard #2

Nee Lungjai as Burmese Gate Guard

Yupin Mu Pae as Karen Begging Mother

Moan Adisak as Burmese Morning Guard #1

Somsak Wongsa as Burmese Dancer Trooper #1

Surachai Muangdee as Burmese Dancer Trooper #2

Mana Sen-Mi as Burmese Patrol Boat Captain

Toole Khan Kham as Burmese Sergeant

Saiwan Lungta as Burmese Trooper - Lt. Aye's Hut

Watcharentr Sedtho as Burmese Young Boy

Rapimpa Dibu as Karen Young Naked Girl

May Kung as Pirate Bar Hooker #1

George Cheung as Tay (archive footage) (uncredited)

Richard Crenna as Col. Samuel Trautman (archive footage) (uncredited)

Matthew Wolf as BBC Reporter (uncredited)