Patricia Clarkson as Mia

Rosario Dawson as Lili

Lyndsy Fonseca as Cheyanne

Ginnifer Goodwin as Charlotte

Jeanne Tripplehorn as Pearl

Emily Skinner as Sally

Carla Gallo as Laura

Aisha Hinds as Bernice

Josh Holloway as Bill

Jennifer Morrison as Sheila

Austin Nichols as Edward

Annie Potts as Helen

Xander Berkeley as Peter

Kathy Najimy as Rocky

Romy Rosemont as Lynne

Tony Shalhoub as Mitch

Jenifer Lewis as Maggie

Tracee Ellis Ross as Alyssa

Jeffrey Tambor as Danny

David Eigenberg as Lenny

Taylor Kinney as Tommy

Bob Newhart as Dr. Roth

Ravi Patel as Dr. Desai

Alan Ruck as Sam Jarente

Scott Wilson as Bill (Older)

Kirk Baily as Scott

Israel Sáez de Miguel as Dimitri

Ava Acres as Pearl at age 7

Josh Dallas as Henry

Harmon Jones as Ben