Cameron Diaz as Amanda

Kate Winslet as Iris

Jude Law as Graham

Jack Black as Miles

Eli Wallach as Arthur

Edward Burns as Ethan

Rufus Sewell as Jasper

Miffy Englefield as Sophie

Emma Pritchard as Olivia

Sarah Parish as Hannah

Shannyn Sossamon as Maggie

Bill Macy as Ernie

Shelley Berman as Norman

Kathryn Hahn as Bristol

John Krasinski as Ben

Alex O'Loughlin as Kissing Couple

Odette Annable as Kissing Couple

Bundle Williams as Girl in Pub

Suzanne Dizon as Newspaper Party Guest

Terry Diab as Night Editor

Kenneth Danziger as Editor

Hope Riley as Sarah Smith-Alcott

Gilbert Esquivel as Gardener

Steven Bruns as Couple on Plane

Nikki Novak as Couple on Plane

Judith Drake as Woman on Plane

Pamela Dunlap as Woman on Plane

Hal Douglas as Movie Trailer Narrator (voice)

Jay Simpson as Limo Driver

Siobhan Pestano as Couple with Dog

Charles Dinsdale as Couple with Dog

Sarah Flind as Market Clerk

Darline Ann Harris as Arthur's Nurse

Marcell Brown as Airport Security

Marina Morgan as Graham's Friend

Lynden Edwards as Graham's Friend

Lydia Blanco Garza as Marta

Jon Prescott as Maggie's Boyfriend

Patrick Cavanaugh as Young Man at WGA

Justin Collins as Young Man at WGA

James Franco as James Franco

Lindsay Lohan as Lindsay Lohan

Dustin Hoffman as Dustin Hoffman

Dani Lennon as Model (uncredited)

Steven Quale as News Reporter (uncredited)

Lasco Atkins as Embankment Pedestrian (uncredited)

Patrizia Barretto as Traveler (uncredited)

Drew Bayers as Man in Airport (uncredited)

Brad Carr as Jakob Ethridge - Airport Passenger (uncredited)

Freddie De Grate as Coach Passenger (uncredited)

Nicholas Downs as Peter (uncredited)

Amber Elizabeth as Shop Customer (uncredited)

Andy Gates as Man on Tube (uncredited)

Elizabeth Hara as Girl in Restaurant (uncredited)

Jake Head as Mixer (uncredited)

Halbert Hernandez as Man in Resturant (uncredited)

Steve Humphreys as Jeffrey (uncredited)

Charles Kellam as Man in Airport (uncredited)

Samantha Kelly as Mrs. Ames - Schultz's Friend (uncredited)

Lucy Lewendon as Passerby (uncredited)

Jamie McCall as Party Guest (uncredited)

Mark A. Nash as Newsroom (uncredited)

Ian Novotny as WGA Man (uncredited)

Vanessa Ross as Lindsay Lohan's Friend (uncredited)

Scott Slifer as Passenger (uncredited)

David Venafro as Usher (uncredited)

Leanne Wilson as Girl in Bar (uncredited)