Ed Helms as Matt

Patti Harrison as Anna

Anna Konkle as Shayleen

Evan Jonigkeit as Bryce

Tig Notaro as Madeline

Nora Dunn as Adele

Fred Melamed as Marty

May Calamawy as Carly

Bianca Lopez as Liz

Terri Hoyos as Dana

Jo Firestone as Tamara

Tucker Smallwood as Carson

Gail Rastorfer as Shelly

Caitlin Kimball as Jackie

Greta Titelman as Charlotte

Rosalind Chao as Dr. Andrews

Sufe Bradshaw as Jean the Technician

Timm Sharp as Jacob

Ellen Dubin as Anna's Mom (voice)

Travis Coles as Carl

Johnathan Fernandez as Zeb

Julio Torres as Jules

Ithamar Enriquez as Andy

Casey Feigh as ER Doctor

Jennifer Churchich as Patron

David Chattam as Men's Moderator

Ayla Rose Barreau as Becca

Lucy Kaminsky as Ivy

Krystle Comer as Pregnant Yoga Student

Vivian Gil as Waiter

Heidi Mendez as Anna's Group Moderator

Gregory Garcia as Disgusted Customer