Ed Helms as Matt

Patti Harrison as Anna

Rosalind Chao as Dr. Andrews

Anna Konkle as Shayleen

Evan Jonigkeit as Bryce

Tig Notaro as Madeline

Nora Dunn as Adele

Fred Melamed as Marty

Sufe Bradshaw as Jean the Technician

May Calamawy as Carly

Ellen Dubin as Anna's Mom (voice)

Tucker Smallwood as Carson

Timm Sharp as Jacob

Jo Firestone as Tamara

Travis Coles as Carl

Johnathan Fernandez as Zeb

Julio Torres as Jules

Bianca Lopez as Liz

Terri Hoyos as Dana

Greta Titelman as Charlotte

Ithamar Enriquez as Andy

Caitlin Kimball as Jackie

Casey Feigh as ER Doctor

Jennifer Churchich as Patron

Gail Rastorfer as Shelly

David Chattam as Men's Moderator

Ayla Rose Barreau as Becca

Lucy Kaminsky as Ivy

Krystle Comer as Pregnant Yoga Student

Vivian Gil as Waiter

Heidi Mendez as Anna's Group Moderator

Gregory Garcia as Disgusted Customer