Will Arnett as John Solomon

Will Forte as Dean Solomon

Kristen Wiig as Janine

Chi McBride as James

Lee Majors as Ed Solomon

Sam Lloyd as Dr. Spencer

Malin Åkerman as Tara

Bill Hader as Recumbent Biker

Jenna Fischer as Michelle

Michael Ormsby as Young John Solomon

Ryan Wynott as Young Dean Solomon

Ryun Yu as Dr. Wang

Chandler Hill as Ron

Charles Rahi Chun as Dr. Wong

Derek Waters as Video Store Clerk

Susanne Wright as Erica

Ashley Johnson as Patricia

Brooke Bloom as Grocery Shopper

Anna Becker as Grocery Checker

Brian Scolaro as Medical Delivery Guy

Stephanie Courtney as Sara

Bob Odenkirk as Jim Treacher

Casey Wilson as Fertility Clinic Receptionist