Ethan Hawke as Vincent Freeman

Uma Thurman as Irene Cassini

Jude Law as Jerome Eugene Morrow

Alan Arkin as Detective Hugo

Loren Dean as Adult Anton Freeman

Gore Vidal as Director Josef

Tony Shalhoub as "German"

Ernest Borgnine as Caesar

Blair Underwood as Geneticist

Xander Berkeley as Dr. Lamar

Jayne Brook as Marie Freeman

Una Damon as Head Nurse

Elias Koteas as Antonio Freeman

Maya Rudolph as Delivery Nurse

Elizabeth Dennehy as Preschool Teacher

Mason Gamble as Younger Vincent

Vincent Nielson as Younger Anton

Chad Christ as Young Vincent

William Lee Scott as Young Anton

Clarence Graham as Personnel Officer

Carlton Benbry as Gattaca Hoover

Susan Jennifer Sullivan as Sequencing Customer

Ken Marino as Sequencing Technician

Cynthia Martells as Cavendish

Gabrielle Reece as Gattaca Trainer

Ryan Dorin as Twelve-Fingered Pianist

Dean Norris as Cop on the Beat

Russell Milton as Gattaca Detective

George Marshall Ruge as Beaten Detective

Steve Bessen as Blood Test Detective

Lindsey Ginter as Mission Commander

Greg Sestero as Gattacan Citizen (uncredited)

Chad Baker as Sequencing Tech (uncredited)

Brandon Ladd Burkey as Janitor #2 (uncredited)

Donna Cihak as Gattican (uncredited)

Dan Griffin as Classmate (uncredited)

Beverly Griffith as Anatomy Teacher (uncredited)

David LeBell as Invalid (uncredited)

Richard Yett as Employee (uncredited)