Philip Seymour Hoffman as Andy Hanson

Ethan Hawke as Hank Hanson

Albert Finney as Charles Hanson

Marisa Tomei as Gina Hanson

Aleksa Palladino as Chris Lasorda

Michael Shannon as Dex

Amy Ryan as Martha Hanson

Sarah Livingston as Danielle

Brían F. O'Byrne as Bobby Lasorda

Rosemary Harris as Nanette Hanson

Blaine Horton as Justin

Arija Bareikis as Kathrine

Leonardo Cimino as William

Lee Wilkof as Jake

Damon Gupton as Doctor

Myra Lucretia Taylor as Grader

Marcia Jean Kurtz as Hotel Receptionist

Adrian Martinez as Security Guard

Patrick G. Burns as Priest

Alice Spivak as Receptionist

Natalie Gold as Secretary

Keith Davis as Attendant

Mateo Gómez as Doorman (as Mateo Gomez)

Chris Chalk as Officer

Sakina Jaffrey as Manager

John Knox as Desk Sergeant

James Lally as Agent

Jordan Gelber as Agent #2

Megan Byrne as Nurse

Guy A. Fortt as Vendor

Meredith Patterson as Andy's Secretary

Tom Zolandz as Junkie

Paul Butler as Detective

Anita Sklar as Mourner #1

Josh Mowery as Mourner #2

Diane Bradley as Mourner #3

Richard Lublin as Mourner #4 (as Richard K. Lublin)

Bob Colletti as Ambulance Driver

Mary DeBellis as Mall Shopper (uncredited)

Alex Emanuel as Bartender (uncredited)

Zeke Hawkins as Hospital Guest (uncredited)

Charles Kopelson as Drunk at Bar (uncredited)

Nicholas E. Pagani as Taxi Driver (uncredited)