Tilda Swinton as Rosetta / Ruby / Marinne / Olive

Jeremy Davies as Sandy

James Urbaniak as Agent Hopper

Karen Black as Dirty Dick

Al Nazemian as Dr. Bea

S.U. Violet as Dr. Aye

Josh Kornbluth as Tim

Thomas Jay Ryan as Preacher

Howard Swain as Alex

Diana Demar as Dana

John Pirruccello as Hair Dresser

Abigail van Alyn as Sandy's Mom

Dick Bright as Phil

John Bradford King as Nathan

Paul Barnett as Sam

Benton Greene as Frank

Diane Luby Lane as Sales Clerk

Paula West as Self

Andrea Zomber as Leonora

Paul Ghiringhelli as Reporter (uncredited)

Tia Hunnicutt as Brazilian CFN (uncredited)

John Larkin as Cop (uncredited)

Dena Martinez as Visna (uncredited)

Johanna Mattox as Waitress (uncredited)

Sumalee Montano as Nelia (uncredited)

Darian O'Toole as Suzie Sexpert (uncredited)

Randy Robertson as Cafe Patron (uncredited)

Sean Savage as Impotent Victim (uncredited)