Owen Wilson as Carl Nargle

Michaela Watkins as Katherine

Wendi McLendon-Covey as Wendy

Ciara Renée as Ambrosia

Lusia Strus as Beverly

Stephen Root as Tony

Lucy Freyer as Jenna

Denny Dillon as PBS Host

Evander Duck Jr. as Reuben

Elisabeth Henry-Macari as Bridget

Michael Pemberton as Dr. Bradford Lenihan

Rob Figueroa as Donald Moore

Elizabeth Loyacano as Alexandra Moore

Sonia Darmei Lopes as Mary

Joel Leffert as Sydney

Noa Graham as Dean Gregory

Paul Kosopod as Bridget's Best Friend

Ryan Czerwonko as Young Bar Regular

Aidan T.K. Baker as Strong Bar Regular

Vin Craig as SuperFan

Chris Gaunt as Waiter

Lynda Suarez as Ambrosia's Mom

Sarah Baker as Lady in the Window

Brit McAdams as The Whittler

Sylvia Fletcher as Ventriloquist

Ryan Gaul as Vermont Mountain Express

Phoenix Na as Female Student

Crystal Tweed as PBS President Vermont

Dina Washington as Ambrosia's Grandma

Colin J. Sweeney as Milk and Cheese Man

Kristin Hensley as Milk and Cheese Woman

Scott Beehner as Newscaster 1

Jen Smedley as Newscaster 2