Millie Bobby Brown as Enola Holmes

Henry Cavill as Sherlock Holmes

David Thewlis as Grail

Louis Partridge as Lord Tewkesbury

Susan Wokoma as Edith

Adeel Akhtar as Lestrade

Sharon Duncan-Brewster as Mira Troy

Helena Bonham Carter as Eudoria Holmes

Sofia Stavrinou as Young Enola

John Parshall as Young Sherlock

Himesh Patel as Dr. Watson

Hannah Dodd as Sarah Chapman / Cicely

Abbie Hern as Mae

Róisín Monaghan as Hilda Lyons

Gabriel Tierney as William Lyon

Catriona Chandler as Agatha Gowerdale

David Westhead as Henry Lyon

Tim McMullan as Charles McIntyre

Lee Boardman as Mr. Bill Crouch

Serrana Su-Ling Bliss as Bessie Chapman

Tony Lucken as Sgt. Beeston

Alessandra Perotto as Peddler

Alan Mitchell as Powdered Face Man

Chris Dunckley as Newspaper Boy

Lenny Rush as Newspaper Boy

Alison Knox as Freda

Christopher Saul as Client

Brahmdeo Shannon Ramana as Client

Karishma Navekar as Client

Clive Ward as Client

Elizabeth Hill as Client

Nick Raggett as Client

Sue Graham as Strong Woman Inmate

Mark Fleischmann as Stage Manager

Stefan Petermann as Young Mycroft

Archie Caswell-Chappell as Boy With Soup

Matthew Brazier as Desk Sergeant

Jules Wallace as Oates

Donovan Louie as Kwan

Nia Gandhi as Doris

Alannah Winn-Taylor as Swollen Jaw Girl

Peter Groom as Bill - Man In Drag

Charlie Nicholson as Pimply Boy

Eleanor Dang as Bessie Picture Double

Charlotte Robinson as Music Hall Dancer

Katelyn Gray as Music Hall Dancer

Preeti Sian as Music Hall Dancer

Sophia Turner as Music Hall Dancer

Annie Bloomfield as Ballroom Dancer

Hannah Bodenham as Ballroom Dancer

Tabitha Bond as Ballroom Dancer

Callum Bowman as Ballroom Dancer

Miekaile Browne as Ballroom Dancer

Alastair Crosswell as Ballroom Dancer

Rory Cubbin as Ballroom Dancer

Ramzan Miah as Ballroom Dancer

James Berkery as Ballroom Dancer

Andres Quero Marin as Ballroom Dancer

Tyler Rainbow as Ballroom Dancer

Yasmin Riley as Ballroom Dancer

Vanessa Vince-Pang as Ballroom Dancer

Madeleine Waters as Ballroom Dancer

Charlotte Woof as Ballroom Dancer

Cecily Beer as Ballroom Musician

Sally Alexandra as Ballroom Musician

Taylor Maclennan as Ballroom Musician

Cormac Browne as Ballroom Musician

Mircea Belei as Ballroom Musician

Boyan Ivanov as Ballroom Musician

Daniel Pemberton as Music Hall Conductor (uncredited)

Philip Gascoyne as Police Officer (uncredited)

Kemal Shah as Upper Middle Class Gentleman