Shia LaBeouf as Stanley "Caveman" Yelnats IV

Khleo Thomas as Hector "Zero" Zeroni

Sigourney Weaver as Louise Walker the Warden

Jon Voight as Marion Sevillo "Mr. Sir"

Patricia Arquette as Katherine "Kissin' Kate" Barlow

Dulé Hill as Sam the Onion Man

Henry Winkler as Stanley Yelnats III

Siobhan Fallon Hogan as Tiffany Yelnats

Tim Blake Nelson as Dr. Pendanski

Eartha Kitt as Madame Zeroni

Brenden Jefferson as Rex "X-Ray"

Jake M. Smith as Alan "Squid"

Byron Cotton as Theodore "Armpit"

Miguel Castro as José "Magnet"

Max Kasch as Ricky "Zigzag"

Zane Holtz as Louis "Barfbag"

Noah Poletiek as Brian "Twitch"

Steven Kozlowski as Lump

Scott Plank as Charles "Trout" Walker

Roma Maffia as Carla Morengo

Ray Baker as Asst. Attorney General

Damien Luvara as Elya Yelnats

Haleigh Ann Trickett as Young Warden

Nathan Davis as Stanley Yelnats II

Rick Fox as Clyde "Sweet Feet" Livingston

Shelley Malil as Landlord

Sanya Mateyas as Myra Menke

Ravil Isyanov as Morris Menke

Ken Davitian as Igor Barkov

Michael Cavanaugh as Judge Austin Gorg

Jim Wilkey as Bus Driver / Kissed Stage Coach Driver

Alex Daniels as Texas Ranger #1

Tom Brainard as Texas Ranger #2

Steven Lambert as Trout Gang #2

Gary Bullock as Prospector

Brian Peck as Townsman

Bruce Ramsay as Prosecutor