Tom Hanks as Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry

Halle Berry as Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym

Jim Broadbent as Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2

Hugo Weaving as Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie

Jim Sturgess as Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law

Bae Doona as Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute

Ben Whishaw as Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman

James D'Arcy as Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist

Zhou Xun as Talbot / Hotel Manager / Yoona-939 / Rose

Keith David as Kupaka / Joe Napier / An-kor Apis / Prescient

Susan Sarandon as Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess

Hugh Grant as Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief

David Gyasi as Autua / Lester Rey / Duophsyte

Robert Fyfe as Old Salty Dog / Mr. Meeks / Prescient 1

Martin Wuttke as Mr. Boerhaave / Guard / Leary the Healer

Robin Morrissey as Young Cavendish

Brody Nicholas Lee as Javier Gomez / Jonas / Zachry's Older Nephew

Ian van Temperley as Enforcer

Amanda Walker as Veronica

Ralph Riach as Ernie

Andrew Havill as Mr. Hotchkiss

Tanja de Wendt as Mrs. Hotchkiss

Raevan Lee Hanan as Little Girl with Orison at Papa Song's / Catkin / Zachry Relative

Götz Otto as Groundsman Withers

Niall Greig Fulton as Haskell Moore's Dinner Guest / Mozza Hoggins

Louis Dempsey as Haskell Moore's Dinner Guest / Jarvis Hoggins

Martin Docherty as Haskell Moore's Dinner Guest / Eddie Hoggins

Alistair Petrie as Haskell Moore's Dinner Guest / Musician / Felix Finch / Lascivious Businessman

Zhu Zhu as Megan Sixsmith / 12th Star Clone

Sylvestra Le Touzel as Haskell Moore's Dinner Guest / Nurse Judd / Aide in Slaughtership

Jojo Schöning as Papa Song Punk

Laura Vietzen as Young Ursula

Thomas Kügel as Vater

Marie Rönnebeck as Ursula's Daughter

Ruby Kastner as Young Girl

Emma Werz as Ursula's Granddaughter

Mya-Lecia Naylor as Miro

Korbyn Hawk Hanan as Adam Grandson

Katy Karrenbauer as Axwoman

Dulcie Smart as Ursula's Mother / Herbalist

Anna Holmes as Scientist / Executive

Shaun Lawton as Secretary

Moritz Berg as Porter

Gigi Lee as Zachry Relative

Genevien Lee as Zachry Relative

Cody Benjamin Lee as Zachry Relative

Heike Hanold-Lynch as Ms. Judd Look-a-like

Victor Solé as Mr. Roderick

Kristoffer Fuss as Lead Enforcer

Marco Albrecht as Scan Enforcer

Gary McCormack as Crane Operator

David Mitchell as Union Spy