Alexander Knox as Woodrow Wilson

Geraldine Fitzgerald as Edith Bolling Galt

Thomas Mitchell as Joseph Tumulty

Ruth Nelson as Ellen Wilson

Cedric Hardwicke as Senator Henry Cabot Lodge

Charles Coburn as Professor Henry Holmes

Vincent Price as William Gibbs McAdoo

William Eythe as George Felton

Mary Anderson as Eleanor Wilson

Ruth Ford as Margaret Wilson

Sidney Blackmer as Josephus Daniels

Madeleine Forbes as Jessie Wilson

Stanley Ridges as Dr. Cary Grayson

Eddie Foy Jr. as Eddie Foy

Charles Halton as Colonel House

Thurston Hall as Senator Edward H. 'Big Ed' Jones

Marcel Dalio as Premier Georges Clemenceau

Katherine Locke as Helen Bones

Stanley Logan as Robert Lansing, Secretary of State

Edwin Maxwell as William Jennings Bryan

Paul Everton as Judge Westcott (uncredited)

J.M. Kerrigan as Edward Sullivan

James Rennie as Jim Beeker

Clifford Brooke as Prime Minister David Lloyd George

Tonio Selwart as Count Von Bernstorff

John Ince as Senator Watson

Charles Miller as Senator Bromfield

Douglas Fairbanks as Douglas Fairbanks - at WWI Rally (archive footage) (uncredited)

John Hamilton as Legislator in Wilson's Office (uncredited)

Ian Wolfe as Reporter (uncredited)

Will Wright as Hughes Campaign Orator in Maine (uncredited)

Eddie Borden as Missouri Delegate (uncredited)

Gino Corrado as Italian Restaurant Waiter (uncredited)

John Davidson as Princeton Team Doctor (uncredited)

Edward Earle as Reporter (uncredited)

Sam Flint as Orator (uncredited)

William Forrest as Minor Role (uncredited)

Reed Hadley as White House Usher (uncredited)

Frank Orth as Smith (uncredited)

Emory Parnell as Chairman of Democratic Committee (uncredited)

Roy Roberts as Ike Hoover - Chief White House Butler (uncredited)

Ralph Sanford as Minor Role (uncredited)

William Yetter Sr. as German Delegate (uncredited)

Harry Carter as Secretary (uncredited)

Gladden James as Redfield (uncredited)

Walter Baldwin as Wilson Campaign Orator (uncredited)

Lester Dorr as Reporter (uncredited)

George Macready as William McCombs (uncredited)