Steve Coogan as Tristram Shandy / Walter Shandy / Steve Coogan

Rob Brydon as Toby Shandy / Rob Brydon

Keeley Hawes as Elizabeth Shandy / Keeley Hawes

Shirley Henderson as Susannah / Shirley Henderson

Raymond Waring as Trim

Conal Murphy as Six-Year-Old Tristam

Joe Williams as Nine-Year-Old Tristam

Paul Kynman as Obadiah

Mark Tandy as London Doctor

Dylan Moran as Dr. Slop

Jack Shepherd as Surgeon

David Walliams as Parson

Jeremy Northam as Mark

Benedict Wong as Ed

Naomie Harris as Jennie

Claire Keelan as Make-Up Assistant

Kelly Macdonald as Jenny

Mark Hadfield as Leo

Elizabeth Berrington as Debbie

Mark Williams as Ingoldsby

Jenny Ogilvie as Sandy

Tony Wilson as Tony Wilson

Justine Mitchell as Tony's Director

Kieran O'Brien as Gary

Roger Allam as Adrian

Ashley Jensen as Lindsey

James Fleet as Simon

Ian Hart as Joe

Ronni Ancona as Anita

Greg Wise as Greg

Paul Rider as Prop Guy

Stephen Fry as Patrick Curator / Parson Yorick

Sara Stewart as Joanna

Gillian Anderson as Widow Wadman / Gillian Anderson

Stephen Rodrick as New York Times Reporter

Rosie Cavaliero as Rachel

Damon Caliendo as Fire Dancer

Andy Callaghan as Playing Film Crew

Richard Tree as Redcoat Officer

Mary Healey as Midwife

Stuart Wilson as Sound Mixer