John Barrymore as Riviere

Helen Hayes as Madame Fabian

Clark Gable as Jules

Lionel Barrymore as Robineau

Robert Montgomery as Auguste Pellerin

Myrna Loy as Wife of Brazilian Pilot

William Gargan as Brazilian Pilot

C. Henry Gordon as Daudet

Leslie Fenton as Jules' Radio Operator / Co-Pilot

Harry Beresford as Pierre Roblet

Frank Conroy as Radio Operator

Dorothy Burgess as Pellerin's Girlfriend

Irving Pichel as Dr. Decosta

Helen Jerome Eddy as Worried Mother

Buster Phelps as Sick Child

Ralf Harolde as Pilot

Marcia Ralston as Nightclub Vamp

Maurice Black as Nightclub Manager (uncredited)

Ed Brady as Radio Operator on Telephone (uncredited)

Sidney D'Albrook as Airport Office Employee (uncredited)

Claire Du Brey as Santiago Nurse (uncredited)

Sherry Hall as Airport Office Employee (uncredited)

Otto Hoffman as Airport Office Clerk (uncredited)

George Irving as Santiago Doctor (uncredited)

Wallace MacDonald as Mechanic (uncredited)

Michael Mark as Airport Office Employee (uncredited)

Francis McDonald as Radioman (uncredited)

Louis Natheaux as Radioman (uncredited)

Inez Palange as Simone's Maid (uncredited)

Edward Peil Sr. as Airport Office Employee (uncredited)

Evelyn Selbie as Mother in Window (uncredited)