Meg Ryan as Annie Reed

Tom Hanks as Sam Baldwin

Ross Malinger as Jonah Baldwin

Bill Pullman as Walter

Rosie O'Donnell as Becky

Barbara Garrick as Victoria

Rob Reiner as Jay

Gaby Hoffmann as Jessica

Rita Wilson as Suzy

Victor Garber as Greg

Tom Riis Farrell as Rob

Carey Lowell as Maggie Baldwin

Le Clanché du Rand as Barbara Reed

Kevin O'Morrison as Cliff Reed

David Hyde Pierce as Dennis Reed

Valerie Wright as Betsy Reed

Frances Conroy as Irene Reed

Tom Tammi as Harold Reed

Calvin Trillin as Uncle Milton

Caroline Aaron as Dr. Marcia Fieldstone

Linda Wallem as Loretta

LaTanya Richardson Jackson as Harriet

Tom McGowan as Keith

Steve Mellor as Wyatt

Marguerite Schertle as Baltimore Waitress

Dana Ivey as Claire

Brian McConnachie as Bob

Matt Smith as Mailman

Amanda Maher as Clarise

Victor Morris as Seattle Maitre D'

Philip Mihalski as Seattle Waiter

Donald J. Lee Jr. as Seattle Detective

Mary A. Kelly as Nervous Woman on Airplane

Diane Sokolow as Tiffany Saleswoman

Hannah Cox as Jessica's Mother

Rich Hawkins as Jessica's Father

Tamara Plank as Stewardess

Michael Badalucco as New York Taxi Dispatcher

Jeff Mazzola as New York Taxi Dispatcher

Philip Levy as Taxi Driver

Julie Janney as Cynthia

Tony Zazula as Maitre D'

John Boylan as Elevator Man

Robert Livingston as Elevator Man

Butch Stevenson as Valet

Sidney Armus as Information Booth Man

Philip Anagnos as Car Driver (uncredited)

Jason Bortz as Baltimore Mail Clerk (uncredited)

Scott Duthie as Tourist (uncredited)

William Rossman as Driver (uncredited)

Nick Taylor as Bartender (uncredited)