Steve Martin as Neal Page

John Candy as Del Griffith

Laila Robins as Susan Page

Michael McKean as State Trooper

Dylan Baker as Owen

Kevin Bacon as Taxi Racer

Olivia Burnette as Marti Page

Carol Bruce as Joy Page

Diana Douglas as Peg

Martin Ferrero as Motel Clerk

Larry Hankin as Doobie

Richard Herd as Walt

Susan Kellermann as Waitress

Matthew Lawrence as Little Neal

Edie McClurg as Car Rental Agent

Susan Isaacs as Marie

John Randolph Jones as Cab Dispatcher

Ben Stein as Wichita Airport Rep

Lyman Ward as John

George Petrie as Martin

Gary Riley as Motel Thief

Charles Tyner as Gus

Lulie Newcomb as Owen's Wife

Nicholas Wyman as New York Lawyer

Gaetano Lisi as Cab Driver - New York

Diana Castle as Stewardess #1

Julie H. Morgan as Stewardess #2

Bill Erwin as Man on Plane

Ruth de Sosa as New York Ticket Agent

Kim Genelle as Receptionist

Grant Forsberg as Brand Manager

David Raiport as Cafe Patron

Andrew J. Hentz as Bus Lover

Karen Meisinger as Bus Loverette

Gary Palmer as Pilot

John Moio as Screaming Driver

Victoria Vanderkloot as Screaming Driver's Wife

William Windom as Mr. Bryant

Troy Evans as Antisocial Trucker

George Sasaki as Plane Passenger (uncredited)