Nicolas Cage as Frank Pierce

Patricia Arquette as Mary Burke

John Goodman as Larry Verber

Ving Rhames as Marcus

Tom Sizemore as Tom Wolls

Marc Anthony as Noel

Mary Beth Hurt as Nurse Constance

Cliff Curtis as Cy Coates

Aida Turturro as Nurse Crupp

Nestor Serrano as Dr. Hazmat

Cynthia Roman as Rose

Sonja Sohn as Kanita

Larry Fessenden as Cokehead

Arthur J. Nascarella as Captain Barney

Martin Scorsese as Dispatcher (voice)

Queen Latifah as Dispatcher Love (voice)

Michael Kenneth Williams as Drug Dealer

Craig muMs Grant as Voice in Crowd

John Heffernan as Mr. Oh

Judy Reyes as ICU Nurse

Afemo Omilami as Griss

Cullen O. Johnson as Mr. Burke

Julyana Soelistyo as Sister Fetus

Graciela Lecube as Neighbor Woman

Marylouise Burke as Neighbor Woman

Phyllis Somerville as Mrs. Burke

Mary Diveny as Neighbor Woman

Tom Riis Farrell as John Burke

Aleks Shaklin as Arguing Russian

Leonid Citer as Arguing Russian

Jesus A. Del Rosario Jr. as Man with Bloody Foot

Bernie Friedman as Big Feet

Theo Kogan as Prostitute

Fuschia! as Prostitute

Matthew Maher as Mr. Oh's Friend

Bronson Dudley as Mr. Oh's Friend

Marilyn McDonald as Mr. Oh's Friend

Ed Jupp Jr. as Homeless Man in Waiting Room

J. Stanford Hoffman as Homeless Man in Waiting Room

Rita Norona Schrager as Concerned Hispanic Aunt

Don Berry as Naked Man

Mtume Gant as Street Punk

Michael A. Noto as Grunt

Omar Scroggins as Bystander

Andy Davoli as Stanley

Charlene Hunter as Miss Williams

Jesse Malin as Club Doorman

Harper Simon as I.B. Bangin'

Joseph Monroe Webb as Drummer

Jon Abrahams as Club Bystander

Charis Michelsen as I.B.'s Girlfriend

Lia Yang as Dr. Milagros

Antone Pagán as Arrested Man

Melissa Marsala as Bridge & Tunnel Girl

Betty Miller as Weeping Woman

Rosemary Gomez as Pregnant Maria

Luis Rodriguez as Carlos

Sylva Kelegian as Crackhead

Frank Ciornei as Dr. Mishra

Catrina Ganey as Nurse Odette

Jennifer Lane Newman as Nurse Advisor

John Bal as Police in Hospital

Raymond Cassar as Police in Hospital

Tom Cappadona as Drunk

Jack O'Connell as Drunk

Randy Foster as Drunk

Richard Spore as Homeless Suicidal

James Hanlon as Fireman

Chris Edwards as Fireman

Mark Giordano as Police Sergeant

Michael Mulheren as Cop in Elevator

David Zayas as Cop in Elevator

Terry Serpico as Cop #1

Floyd Resnick as Cop #3

Megan Leigh as Surgeon

David Vasquez as Screaming Man

Joseph P. Reidy as ICU Doctor

Erica Bamforth as Urchin Prostitute (uncredited)

Peju Bamgboshe as Child Zombie (uncredited)

Carolyn Campbell as Policewoman (uncredited)

Michael Carbonaro as Club Kid (uncredited)

Joe Connelly as Catatonic Patient in Suede Coat (uncredited)

Brian Smyj as Cop #2 (uncredited)