Glenn Close as Diana

Elizabeth Banks as Isabel

Eric Bogosian as Henry

Jesse Bradford as Alec

Matthew Davis as Mark

Andrew Howard as Ian

Thomas Lennon as Marshall

John Light as Peter

Susan Malick as Rachel

James Marsden as Jonathan

Michael Murphy as Jesse

Denis O'Hare as Andrew

Isabella Rossellini as Liz

George Segal as Rabbi Mendel

Rufus Wainwright as Jeremy

Angel Desai as Laura

Katie Kreisler as Helen

Regina Schneider as Amanda

Jim Parsons as Oliver

Philip Tabor as Paul

Jonathan Walker as Michael

Chandler Williams as Juilliard Macbeth

Bess Wohl as Juilliard Lady Macbeth

Daniel Neiden as Wedding Rabbi

Rachel Siegel as Autograph Seeker

Jordi Vilasuso as Benjamin's Ex

Nat DeWolf as Benjamin's Ex

Joel de la Fuente as Benjamin's Ex

Melanie R. Orr as Scorned Woman

Jane Nichols as Guest 1

Don Fitzgerald as Built Guy

Meghan Glennon as Party Girl

Winsome Brown as SNL Writer

Michael Goldstrom as SNL Writer

Steven Glenn as Guest 2

Alice Tan Ridley as Subway Singer

Caroline Clay as Subway Woman

Cindy Adams as Self

Alexander Lange as Guest 3

Manny Siverio as Subway Mugger

Frank Shattuck as EMT

D'Vorah Bailey as Police Officer

Jan Ellis as Hospital Receptionist

Liza Colón-Zayas as Ana