Paul Muni as Antonio 'Tony' Camonte

Ann Dvorak as Francesca 'Cesca' Camonte

Karen Morley as Poppy

Osgood Perkins as John 'Johnny' Lovo

C. Henry Gordon as Insp. Ben Guarino

George Raft as Guino Rinaldo

Vince Barnett as Angelo

Boris Karloff as Gaffney

Purnell Pratt as Mr. Garston, publisher

Tully Marshall as Managing Editor

Inez Palange as Mrs. Camonte

Edwin Maxwell as Chief of Detectives

Jean Harlow as Blonde at Paradise Club

Henry Armetta as Pietro, the Barber (uncredited)

Gus Arnheim as Orchestra Leader (uncredited)

Eugenie Besserer as Citizens Committee Member (uncredited)

Maurice Black as Jim, the Headwaiter (uncredited)

James Conaty as Nightclub Patron (uncredited)

Gino Corrado as Waiter at Columbia Cafe (uncredited)

Virginia Dabney as Mabel (uncredited)

William B. Davidson as Citizens Committee Member (uncredited)

James Durkin as Newspaper Man (uncredited)

Bill Elliott as Man Outside Theatre (uncredited)

Eddie Fetherston as Reporter (uncredited)

Paul Fix as Hood with Gaffney (uncredited)

Dick Gordon as Nightclub Patron (uncredited)

Howard Hawks as Man on Bed (uncredited)

Brandon Hurst as Citizens Committee Member (uncredited)

Sydney Jarvis as Bartender (uncredited)

John Kelly as One of Costillo's Hoods (uncredited)

John Lee Mahin as MacArthur from the Journal (uncredited)

Hank Mann as Stag Party Janitor (uncredited)

Frank McLure as Nightclub Patron (uncredited)

Frank Mills as Hood (uncredited)

William H. O'Brien as Waiter (uncredited)

Dennis O'Keefe as Night Club Patron (uncredited)

Jack Perry as One of Costillo's Hoods (uncredited)

Pedro Regas as Tony - Bodyguard (uncredited)

Warner Richmond as Cesca's Dance Partner (uncredited)

Constantine Romanoff as Henchman (uncredited)

Ronald R. Rondell as Hood (uncredited)

Bert Starkey as Epstein - Lawyer (uncredited)

Charles Sullivan as One of Costillo's Hoods (uncredited)

Harry Tenbrook as One of Costillo's Hoods (uncredited)

Helen C. Thompson as Sadie Thompson (uncredited)

Nick Thompson as One of Costillo's Hoods (uncredited)

Ellinor Vanderveer as Theatregoer (uncredited)

Harry J. Vejar as Big Louis Costillo (uncredited)

Sailor Vincent as One of Costillo's Hoods (uncredited)

Douglas Walton as Cesca's Boyfriend (uncredited)

Stanhope Wheatcroft as Nightclub Patron (uncredited)