Jake Gyllenhaal as Searcher Clade (voice)

Dennis Quaid as Jaeger Clade (voice)

Jaboukie Young-White as Ethan Clade (voice)

Gabrielle Union as Meridian Clade (voice)

Lucy Liu as Callisto Mal (voice)

Alan Tudyk as Narrator / Radio Host 1 / Duffle (voice)

Jonathan Melo as Diazo (voice)

Abraham Benrubi as Lonnie Redshirt (voice)

Karan Soni as Caspian (voice)

Adelina Anthony as Pulk (voice)

Nik Dodani as Kardez (voice)

Francesca Reale as Azimuth (voice)

Emily Kuroda as Ro (voice)

Reed Buck as Rory (voice)

Katie Lowes as Radio Host 2 (voice)

LaNisa Renee Frederick as Client #2 (voice)

Dave Kohut as Client #3 (voice)

Alice Kina Diehl as Client #4 (voice)