Daniel Craig as Benoit Blanc

Edward Norton as Miles Bron

Janelle Monáe as Andi Brand

Kathryn Hahn as Claire Debella

Leslie Odom Jr. as Lionel Toussaint

Kate Hudson as Birdie Jay

Dave Bautista as Duke Cody

Jessica Henwick as Peg

Madelyn Cline as Whiskey

Noah Segan as Derol

Jackie Hoffman as Ma

Dallas Roberts as Devon Debella

Ethan Hawke as Efficient Man

Hugh Grant as Phillip

Stephen Sondheim as Stephen Sondheim

Natasha Lyonne as Natasha Lyonne

Kareem Abdul-Jabbar as Kareem Abdul-Jabbar

Serena Williams as Serena Williams

Yo-Yo Ma as Yo-Yo Ma

Joseph Gordon-Levitt as Hourly Dong (voice)

Adele Franck as Claire's Assistant

Jacek Czajka as Lab Worker

Dan Chariton as Dr. Pierre Bonassus

Eddie Gorodetsky as Dr. Peter Clayton

Coco Shinomiya as Emiko Yamane

Dilcia Barrera as Dr. Dilcia Cabrera

Mark Newman as Dr. Mark Swifton

Adam Davenport as Model

Lauren Ivy as Dancer

Momo Pićurić as Vampire in Tuxedo

N.J. Gentry as Nikos

Ali Goksoy as Andino

James Payton as Lawyer

T. Florian Karnowski as Judge

Angela Lansbury as Angela Lansbury

Jake Tapper as Jake Tapper (uncredited)

Panagiotis Margetis as Hotel Server (uncredited)