Benicio del Toro as Ernesto Che Guevara

Carlos Bardem as Moisés Guevara

Demián Bichir as Fidel Castro

Joaquim de Almeida as President René Barrientos

Pablo Durán as Pacho (Alberto Fernández Montes de Oca)

Eduard Fernández as Ciro Algarañaz

Marc-André Grondin as Régis Debray

Óscar Jaenada as Darío (David Ardiazola)

Kahlil Méndez as Urbano (Leonardo Tamayo Núñez)

Cristian Mercado as Inti (Guido Peredo Liegue)

Jordi Mollà as Captain Mario Vargas

Gastón Pauls as Ciro Bustos

Antonio Peredo as Coco (Roberto Peredo Liegue)

Jorge Perugorría as Joaquin (Juan Vitalo 'Vilo' Acuña)

Lou Diamond Phillips as Mario Monje

Franka Potente as Tania (Haydee Tamara Bunke Bider)

Othello Rensoli as Pombo (Harry Villegas Tamayo)

Armando Riesco as Benigno (Dariel Alarcón Ramirez)

Néstor Rodulfo as Miguel (Manuel Hernández Osorio)

Catalina Sandino Moreno as Aleida March

Norman Santiago as Tuma (Carlos Coello)

Rodrigo Santoro as Raúl Castro

Mark Umbers as George Roth

Yul Vazquez as Alejandro Ramírez

María D. Sosa as Aleidita

Raúl Beltrán as Bolivian Customs Agent #1

Raúl 'Pitín' Gómez as Bolivian Customs Agent #2

Paty M. Bellott as Woman at Airport

Ezequiel Díaz as Loro (Jorge Vázquez Viaña)

Juan Salinas as Polo (Apolinar Aquino Quispe)

Luis Muñoz as Serapio Aquino Tudela

Lorenzo Ariel Muñoz as Camba (Orlando Jiménez Baznán)

Aarón Vega as Ricardo (José María Martínez Tamayo)

Giraldo Moisés as Braulio (Israel Reyes Zayas)

Rubén Ochandiano as Rolando (Eliseo Reyes Rodriguez)

Roberto Guilhon as Ernesto (Freddie Maymura Hurtado)

Carlos Acosta-Milian as Antonio Domínguez Flores

Edgardo Rodríguez as Arturo (René Martínez Tamayo)

José Juan Rodríguez as Moro (Octavio de la Concepción y de la Pedraja)

Daniel Larrazábal as Ñato (Julio Luis Méndez Korne)

Wilder Salinas as Julio

Jimmy A. Céspedes as Eustaquio (Lucio Edilberto Galván Hidalgo)

Eitán Vázquez as Salustio Choque Choque

Oscar Aviles as Pedro (Antonio Jiménez Tardio)

Ruben Salinas as Paco (José Castillo Chávez)

Daniel Aguirre as Aniceto Reinaga

Miguel Villarroel as Carlos

Diego Ortiz as Willy (Simón Cuba Saravia)

Jorge Arturo Lora as Chapaco (Jaime Arana Campero)

Marisé Álvarez as Vilma Espín

Eduardo Espinosa as El Vallegrandino

Antonio de la Torre as Lieutenant Carlos Fernández

Marco Antonio as Plainclothes Policeman

Luis Bredow as Honorato Rojas

María Cristina Calá as Honorato's Wife

Edison Narváez as Pablito (Francisco Huanca)

Bart Santana as Daniel (Pastor Barrera Quintana)

Raúl Núñez as Eusebio Tapia Arune

Jesús Carrillo as Vicente Roeabado Terrazas

José Julio Park as Chino (Juan Pablo Chang)

Juan Carlos Vellido as Major Hernán Plata

Raúl Arévalo as Captured Soldier #1

Daniel Holguín as Captured Soldier #2

Sergio Deustua as Captured Soldier #3

Tom Minder as American #1

Andrew Petrotta as American #2

Frederic W. Brost as American #3

Geischglin Rojas as Padilla

Stephen Casmier as Captain Mitchell

James D. Dever as Major Ralph 'Pappy' Shelton

Roberto San Martín as Captain Gary Prado

Luis Callejo as Bolivian Interrogator

Matt Damon as Fr. Schwartz

Eduard Sanjines as Reporter #1

Diego Salazar as Reporter #2

René Aragón as Reporter #3

Pedro Casablanc as Colonel Joaquín Zenteno

Tomás del Estal as General Alfredo Ovando Candía

David Zambrana as Chingolo

Flavio Morales as Soldier Playing Possum

José María Piñeda as Hiding Soldier

Mónica Montoya as Store Owner

Saúl Avila as Coca Vendor

Miguel Antelo as Prado's Radio Operator

David Selvas as Lieutenant Colonel Andrés Selich

Jesús Carroza as Eduardo

César Salgado as Guard at Door

Martín Bello as Bolivian Soldier

Vismark Tito Rojas as Lieutenant Eduardo Huerta

Enrique Arce as Lieutenant Carlos Pérez

Cristhian Esquivel as Sergeant Mario Terán

Benjamín Benítez as Rudolfo (uncredited)

Mariu Bárcena as Embassy Girl (uncredited)

Mizan Kirby as Ernesta Loud Demonstrator (uncredited)

Antonio Pardo as Ranger Boliviano (uncredited)

Jason Rivera as Un delegate (uncredited)

Uzimann as Indian Diplomat (uncredited)

Steven Weisz as News Cameraman (uncredited)