Benicio del Toro as Ernesto Che Guevara

Demián Bichir as Fidel Castro

Santiago Cabrera as Camilo Cienfuegos

Vladimir Cruz as Ramiro Valdés Menéndez

Alfredo de Quesada as Israel Pardo

Jsu Garcia as Jorge Sotus

Kahlil Méndez as Leonardo Tamayo Núñez

Elvira Mínguez as Celia Sánchez

Andres Munar as Joel Iglesias Leyva

Julia Ormond as Lisa Howard

Jorge Perugorría as Vilo (Juan Vitalo Acuña)

Edgar Ramírez as Ciro Redondo García

Victor Rasuk as Rogelio Acevedo

Othello Rensoli as Pombo (Harry Villegas)

Armando Riesco as Benigno (Dariel Alarcón Ramírez)

Catalina Sandino Moreno as Aleida March

Roberto Santana as Juan Almeida

Norman Santiago as Tuma (Carlos Coello)

Rodrigo Santoro as Raúl Castro

Unax Ugalde as Vaquerito

Ramon Fernandez as Hector

Roberto Urbina as Guile Pardo

Yul Vazquez as Alejandro Ramirez

Oscar Isaac as U.N. Interpreter

Pablo Guevara as Dinner Guest #1

Franklin Díaz as Dinner Guest #2

Armando Suárez Cobián as Dinner Guest #3

María Isabel Díaz Lago as María Antonia

Mateo Gómez as Cuban Diplomat #1

Jose Caro as Esteban

Pedro Adorno as Epifanío Díaz

Luis Alfredo Rodríguez Sánchez as Rebel Messenger #1

Marisé Álvarez as Vilma Espín

Christian Nieves as Oñate Cantinflás

Liddy Paoli Lopez as Quike Escalona

Francisco Cabrera as Rebel Guide

Pedro Telémaco as Eligio Mendoza

Yamil "Milo" Adorno as Mario Leal

Miguel Ángel Suárez as Army Doctor

Juan Pedro Torriente as Pedro Chape

Io Bottoms as Make-Up Artist

Manuel Cabral as Cuban Man at Bar #1

Oscar A. Colon as Cuban Man at Bar #2

Sam Robards as Tad Szulc

Jay Potter as Richard Hottelet

Stephen Mailer as Paul Niven

René Lavan as Cuban Diplomat #2

Octavio Gómez Berríos as Otto

Blanca Lissette Cruz as María

Laura Andújar as Laura

Georgina Borri as Old Woman #1

Alejandro Renteria as Umberto

Israel Lugo as Omar

Bryant Huffman as Cuervo

Xavier Morales as Esteban's Accomplice

José Luis Gutiérrez as Polo

Jon DeVries as Sen. Eugene McCarthy

Leslie Lyles as Partygoer #1

Meg Gibson as Partygoer #2

Alex Manette as Partygoer #3

Elvis Nolasco as Partygoer #4

Sheridan Lowell as Partygoer #5

Eugenio Monclova as Emilio Cabrera

Jose A. Nieves as Dr. Julio Martínez Páez

Luis Gonzaga Hernandez as Lalo Sardiñas

Joksan Ramos as Raúl Chibás

Javier Ortiz as Felipe Pazos

Luis Rosario as Rebel Luis

Osmin Hernandez as Gustavo

Julio Cesar Morales as Jesús

Leonardo Castro Sitiriche as Army Medic

Oscar De La Fe Colon as Bazooka Guy #1

Luis Arriaga as Bazooka Guy #2

Monique Gabriela Curnen as Secretary

P.J. Benjamin as Captain Stanton

Al Espinosa as Angry Demonstrator #1

Ana Maria Andricain as Angry Demonstrator #2

Michael Countryman as U.S. Ambassador Stevenson

Jorge Armando as Enrique Acevedo

Aris Mejias as Carmen

Carlitos Ruiz Ruiz as Ventriloquist (Albertico)

Victoria Espinosa as Old Woman #2

Joe Urla as Nicaragua Ambassador

Diego Arria as Venezuela Ambassador

Omar Rodríguez as Panama Ambassador

Eduardo Cortés as Sánchez Mosquera

Joaquín Méndez as Faustino Pérez

Pablo Venegas Colón as René Ramos Latour

Jerry Nelson Soto as Nico Torres

José Brocco as Ovidio Díaz Rodríguez

Juan Carlos Arvelo as Rolando Cubela

Yamil Collazo as Enrique Oltuski

Roy Sánchez-Vahamondes as Faure Chomón

Alejandro Carpio as Eloy Gutiérrez Menoyo

Andres Santiago Bravo as Hermes Peña Torres

Aurelio Lima as Victor Bordón Machado

Alba Caraballo as Aleida's Friend

Doel Alicea as Oltuski's Messenger

Rafa Alvarez as Lieutenant Pérez Valencia

José Cotté as Dr. Fernández Mell

Naya Tanya Rivera as Woman in Crowd

Néstor Rodulfo as Miguel (Manuel Hernández Osorio)

Luis Alberto García as Colonel Joaquín Casillas Lumpuy

Teófilo Torres as Colonel Hernández

Ernesto Ruiz Faxas as Fernández Suero

Ricardo Álvarez as Antonio Jiménez

Miguel Rodarte as Man with Sledgehammer

Rafael Simón as Rebel Messenger #2

Bruno Bichir as Colonel Rojas

Gerardo Albarrán as Police Officer

Guillermo Ríos as Comandante Gómez Calderón

Victor Angulo Villacis as Red Cross Worker

Fernando Gutiérrez Vargas as Aide to Hernández

Ramiro Garza Balboa as Man Greeting Che

Carmen Mahiques as Cook at Cuban Embassy

Euriamis Losada as Carlos

Jorge Alberti as Soldier Hector (uncredited)

Fernando Arroyo as Soldier (uncredited)

Javier Bellido Cintrón as Soldier Jose (uncredited)

Lou D'Amato as U.N. Delegate (uncredited)

Ramiro 'Ramir' Delgado Ruiz as Wounded Rebel (uncredited)

Dave Dyshuk as Press Photogropher (uncredited)

Jonathan Fret as Aleida's Companion (uncredited)

Brian Hopson as U.N. Delegate (uncredited)

Rebecca Merle as Protestor at United Nations (uncredited)

Jean Pierre Prats as Soldier (uncredited)

Alexandra Tejeda Rieloff as U.N. Protester (uncredited)

Ektor Rivera as Batista Soldier (uncredited)

Kent Sladyk as Romanian Diplomat at U.N. (uncredited)

Susie Stewart Rubio as Protester (uncredited)

Guillermo Valedón as David Salvador (uncredited)

Gerardo José Vega as Cuban Rebel (uncredited)

Tania Vega as Juan Carlos Esteves's Daughter (uncredited)