Brady Noon as Greg Heffley (voice)

Ethan William Childress as Rowley Jefferson (voice)

Hunter Dillon as Rodrick Heffley (voice)

Erica Cerra as Susan Heffley (voice)

Chris Diamantopoulos as Frank Heffley (voice)

Ed Asner as Grandpa Heffley (voice)

Linda Lavin as Barb (voice)

Loretta Devine as Irene (voice)

Priscilla Lopez as Merle (voice)

Nathan Arenas as Mackie (voice)

Albert Tsai as Drew (voice)

Hudson Yang as Larry (voice)

Jimmy Tatro as Bill (voice)

Kimberly Brooks as News Anchor (voice)

Gracen Newton as Manny (voice)

Vincent Tong as Leland (voice)

Veena Sood as Elevator Lady (voice)

Ava Acres as Additional Voices (voice)