LeBron James as LeBron James

Don Cheadle as Al G. Rhythm

Cedric Joe as Dominic 'Dom' James

Jeff Bergman as Bugs Bunny / Sylvester / Yosemite Sam / Fred Flintstone (voice)

Gabriel Iglesias as Speedy Gonzales (voice)

Zendaya as Lola Bunny (voice)

Eric Bauza as Daffy Duck / Porky Pig / Foghorn Leghorn / Elmer Fudd (voice)

Candi Milo as Granny (voice)

Bob Bergen as Tweety Bird (voice)

Fred Tatasciore as Taz (voice)

Anthony Davis as Anthony Davis / The Brow

Damian Lillard as Damian Lillard / Chronos

Klay Thompson as Klay Thompson / Wet-Fire

Nneka Ogwumike as Nneka Ogwumike / Arachnneka

Diana Taurasi as Diana Taurasi / White Mamba

Sonequa Martin-Green as Kamiyah James

Ceyair J Wright as Darius James

Harper Leigh Alexander as Xosha James

Khris Davis as Malik

Xosha Roquemore as Shanice James

Stephen Kankole as Young LeBron (13 Years)

Jalyn Hall as Young Malik (13 Years)

Wood Harris as Coach C

Jordan Thomas as Young Boy

Sue Bird as Sue Bird

Draymond Green as Draymond Green

A’ja Wilson as A’ja Wilson

Randy Mims as Barbershop Customer

Gerald 'Slink' Johnson as Warner Bros. Security Guard

Sarah Silverman as Warner Bros. Executive

Steven Yeun as Warner Bros. Executive

Ernie Johnson as Game Announcer

Lil Rel Howery as Game Announcer

Michael B. Jordan as Michael B. Jordan

Rosario Dawson as Wonder Woman (voice)

Justin Roiland as Rick Sanchez / Morty Smith (voice)

Kimberly Brooks as Additional Voices (voice)

Skyler Bible as MoCap Performer (uncredited)