Robert De Niro as John Wesley “Jack” Walsh

Charles Grodin as Jonathan Mardukas aka “The Duke”

Yaphet Kotto as Alonzo Mosely, Special Agent, F.B.I.

John Ashton as Marvin Dorfler, Headhunter

Dennis Farina as Jimmy Serrano, Chicago mobster

Joe Pantoliano as Eddie Moscone, Bail Bonder

Richard Foronjy as Tony Darvo, Serrano's henchman

Robert Miranda as Joey, Serrano's henchman

Jack Kehoe as Jerry Geisler, Tony's secretary

Wendy Phillips as Gail, Jack's ex-wife

Philip Baker Hall as Sidney, Chicago mobster

Tom Irwin as F.B.I. Agent Perry

Jimmie Ray Weeks as F.B.I. Agent Tuttle

Danielle DuClos as Denise Walsh, Jack's daughter

Tom McCleister as Red Wood, Bar Tender

Mary Gillis as Bus Ticket Clerk

John Toles-Bey as Monroe Bouchet

Thomas J. Hageboeck as Sergeant Gooch

Stanley White as Stanley

Scott McAfee as Boy on Plane

Linda Cerasuolo as Car Rental Clerk

Lois Smith as Mrs. Nelson, Mardukas's Friend

Fran Brill as Dana Mardukas, Jonathan's Wife

Michael Hawkins as FBI Surveillance Agent #1

John Hammil as FBI Surveillance Agent #2

Lou Felder as Airline Pilot

Cameron Milzer as Stewardess #1

Sonia M. Roberts as Stewardess #2

Sam Sanders as Train Porter

Frank Pesce as Carmine

Paul Joseph McKenna as Ohio Policeman

Matt Jennings as Jason

Rosemarie Murphy as Coffee Shop Waitress

Jack N. Young as Amarillo Desk Sergeant

Robert Coleman as Native American

William Robbins as Native American

Wilfred Netsosie as Native American

Sherman L. Robbins as Native American

Dale Beard Jr. as Native American

Thomas Nez as Native American

Richard Gonzalez as Bar Cashier

Bill Fritz as Bar Customer

Pete Jensen as Flagstaff Police Captain

Andy Charnoki as Flagstaff Sheriff

Tracey Walter as Diner Counter Man

Robert Vento as Serrano Bodyguard

Joe "Tippy" Zeoli as Serrano Bodyguard

James Portolese as Serrano Bodyguard

Armando Muniz as Serrano Bodyguard

Dan York as Las Vegas FBI Agent #1

Rowdy Burdick as Las Vegas FBI Agent #2

Varnoy Lee as Airport Porter

Bob Maroff as L.A. Taxi Driver

Martin Brest as Airline Ticket Clerk (uncredited)

Lisa Burnett as Undercover Cop (uncredited)

George D. Miklos as Airport Manager (uncredited)

Robert Minkoff as Man (uncredited)

Marguerite Nocera as Ticket Clerk (uncredited)

Terry Ray as Deplaning Passenger (uncredited)

Jock L. Schloss as Man (uncredited)

D. Danny Warhol as Station Commuter (uncredited)