Nathan Fillion as Bill Pardy

Michael Rooker as Grant Grant

Elizabeth Banks as Starla Grant

Gregg Henry as Jack MacReady

Tania Saulnier as Kylie Strutemyer

Don Thompson as Wally

Brenda James as Brenda Gutierrez

Jennifer Copping as Margaret

Jenna Fischer as Shelby

Haig Sutherland as Trevor

William MacDonald as Mr. Strutemyer

Iris Quinn as Mrs. Strutemyer

Matreya Fedor as Emily Strutemyer

Amber Lee Bartlett as Jenna Strutemyer

Xantha Radley as Uptight Mom

Dustin Milligan as Drawing Boy

Lloyd Kaufman as Sad Drunk

Zak Ludwig as Gina Kid

Tom Heaton as Tourneur

Mary Black as Woman in Basement

Ben Cotton as Charlie

Lorena Gale as Janene

Dee Jay Jackson as Dwight

Nicholas Podbrey as Diseased Grant part 1

Malcolm Scott as Dude Joining Grant

Darren Shahlavi as Brenda's Husband

Kathryn Kirkpatrick as Karaoke Woman

Corb Lund as Lead Singer

Michael Cromien as Fitzgibbon

Robert Musnicki as Diseased Leader

Stephen Park as Gleeked on Guy

Nicholas Podbrey as Diseased Grant #1

Jeny Cassady as Diseased Grant #2

Alette Falle as Diseased Grant #3

Matt McInnis as Head-Shot Norman

James Gunn as Hank (uncredited)

Magda Apanowicz as Friend (uncredited)

Rick Morwick as Truck Driver (uncredited)

Rob Zombie as Dr. Karl (voice)

Mark Torgl as Melvin Junko (Archive footage)