Daniel Radcliffe as 'Weird Al' Yankovic

Evan Rachel Wood as Madonna

Rainn Wilson as Dr. Demento

Toby Huss as Nick Yankovic

Jack Lancaster as Jim

Spencer Treat Clark as Steve

Tommy O'Brien as Bermuda

Arturo Castro as Pablo Escobar

Julianne Nicholson as Mary Yankovic

Diedrich Bader as Grizzled Narrator (voice)

Lin-Manuel Miranda as Doctor

Richard Aaron Anderson as Young Al

Thomas Lennon as Salesman

David Bloom as Teenage Al

Keanush Tafreshi as Kip

Andrew Steven Hernandez as Robbie

Paloma Esparza Rabinov as Hipster Teen

Scott Aukerman as Police Officer

Johnny Pemberton as Johnny Barf

Jonah Ray Rodrigues as Jonah Barf

Jeremy Bolm as Jeremy Barf

Eric Appel as Captain Buffoon (voice)

"Weird Al" Yankovic as Tony Scotti

Will Forte as Ben Scotti

Patton Oswalt as Heckler

Michael McKean as Sleazy MC

Dot-Marie Jones as Mama Bear

Dean Sharpe as Bartender

Jorma Taccone as Pee-Wee Herman

Demetri Martin as Tiny Tim

Paul F. Tompkins as Gallagher

Akiva Schaffer as Alice Cooper

Conan O'Brien as Andy Warhol

Emo Philips as Salvador Dali

Nina West as Divine

Jack Black as Wolfman Jack

David Dastmalchian as John Deacon

Anthony N. as Security Guard

Quinta Brunson as Oprah Winfrey

Julie Chang as Connie Chung

Josh Groban as Waiter

Seth Green as Radio DJ (voice)

Constantine Rousouli as Cone-Bra Dancer #1

James Brown III as Cone-Bra Dancer #2

Rocky Abou-Sakher as Terrorist Diner Patron

Chris Ryan as Kidnapper

Mike Escamilla as Guard #1

Chad Guerrero as Guard #2

Cesar Ramirez as Mariachi Band Member #1

Omar Estrada as Mariachi Band Member #2

Cesar Chavira as Mariachi Band Member #3

Jimmy Walker Jr. as Floor Manager

Trenyce as Diana Ross

James Preston Rogers as Hulk Hogan

William Guirola as Sicario

Paul Riley Fox as Elton John (uncredited)

Gordon Tarpley as David Bowie (uncredited)

Lisa Margaroli as Elvira, Mistress of the Dark (uncredited)

Erin O'Shea as Kate Pierson (uncredited)