Breckin Meyer as Josh

Seann William Scott as E.L.

Amy Smart as Beth

DJ Qualls as Kyle

Paulo Costanzo as Rubin

Rachel Blanchard as Tiffany

Anthony Rapp as Jacob

Andy Dick as Motel Clerk

Ethan Suplee as Ed

Edmund Lyndeck as Barry's Grandpa

Jessica Cauffiel as The Wrong Tiffany

Marla Sucharetza as Sperm Bank Nurse

Ellen Albertini Dow as Barry's Grandma

Fred Ward as Earl Edwards

Tom Green as Barry

Horatio Sanz as French Toast Guy

Rhoda Griffis as Tour Group Mom

Kohl Sudduth as Mark

Wendell B. Harris Jr. as Professor Anderson

Rini Bell as Carla

Jaclyn DeSantis as Heather

Aliya Campbell as Wendy

Kim Fox as Target Clerk

Patricia Gaul as Cookie Edwards

Richie Dye as Duffy

Mary Lynn Rajskub as Blind Brenda

Tim Ware as Officer Bortz

Julia Wright as Joyce

Paula Claire Jones as Stephanie

Richard Peterson as Michael

Phe Caplan as Boston Coed

Avery Kidd Waddell as Jeff

Omar J. Dorsey as Lawrence

Preston Wigasi Brant as Chris

Mia Amber Davis as Rhonda

Jimmy Kimmel as Corky the Dog (Voice)

Bethany Sacks as Lisa

Charlie McWade as Brian

Todd Barry as Campus Security #1

Bill Rowell as Campus Security #2

Bill Gribble as Bomb Squad Detective

Guenevere Rodriguez as Tour Group

Al Wiggins as Tour Group

Lisa Chyn as Tour Group

Daniel Emery Taylor as Tour Group

Rachel Marinacci as Tour Group

Bob Place as Tour Group

Frank Girardeau as Tour Group

Marla Malcolm as Tour Group

Matt Walsh as Crime Scene Photographer

John Ross Bowie as Waiter

Cristen Coppen as Kim

Cleo King as Woman on Bus

Lori Beth Sikes as Party Guest

Kellie Garrigan as Party Guest

Michael Cornier as Party Guest

Frank Cooper as Party Guest

Mark Bez as Party Guest

Andrew Fowler as Party Guest

Paul Simpson as Party Guest

Krew Keth as Party Guest

Marc Gordon as Stepper

Tharon Johnson as Stepper

Raymond DeLoatch as Stepper

Will Aklin as Stepper

Calvin J. Wilson as Stepper

Benjamin Booker as Stepper

Bridgett Wise as Barry's Girl

Aerica D'Amaro as Barry's Girl

Todd Phillips as Foot Lover

Deborah Zoe as E. L.'s Girlfriend

Johnny Genius as Party Band

Moses as Party Band

Tom Peyton as Party Band

Ben Kramer as Party Band

Eric Tobias as Party Band