Rob Lowe as Drew Peterson

Kaley Cuoco as Stacy Peterson

Catherine Dent as Karen Chojnacki

James C. Burns as Peter

Krista Kalmus as Brianna Cales

Cara Buono as Kathleen Savio

Charlie Koznick as Joe Hosey

Danielle Savre as Chloe Roberts

James Karen as Pastor Tom Keller

Natalie Smyka as Lauren

William Mapother as Glenn Levecke

Teddy Sears as Mike Adler

John Asher as Neighbor Brad

David Chisum as Rick

Jonathan Scarfe as Jeff Aberdeen

Romy Rosemont as Sofia

Dameon Clarke as State Detective Franklin

Ryan Sands as State Detective Rogers

Harrison Forsyth as Justin Peterson

Tanner Maguire as Zach Peterson

Steven Crowley as Scott

Mike Carlucci as Jay the Disc Jockey

Gordon Greene as Jasper

James Ellis Lane as Officer Jim

Tom Yi as Medical Examiner

Bob Kaple as TV Reporter

Olga Ospina as TV Reporter

Steve Tom as Newspaper Editor

Adam Roa as Jimmy / Man In Handcuffs

Sarah Domin as Pretty Woman at Party

Wesley Thompson as Principal

Jamie Hagan as Drunk Woman / Regina

Anderson Cooper as Hinself (Archivefootage)

Isabella Interian as Extra

Larry King as Himself (Archivefootage)

Matt Lauer as Himself (Archivefootage)

Vyas Sharma as Hotel Employee

Meredith Vieira as Herself (Archivefootage)

Aaron Eschenburg as Sound Man (uncredited)

Jack Mahrt as Cop-police car driver (uncredited)

Stephane Nicoli as Boom Operator (uncredited)

Lauren Emily Vaughan as Chloe's Girlfriend (uncredited)