Whoopi Goldberg as Jane Deluca

Mary-Louise Parker as Robin

Drew Barrymore as Holly Pulchik-Lincoln

Matthew McConaughey as Abe Lincoln

James Remar as Alex

Billy Wirth as Nick

Anita Gillette as Elaine

Dennis Boutsikaris as Massarelli

Estelle Parsons as Louise

Amy Aquino as Anna

Stan Egi as Henry

Stephen Gevedon as Johnny Figgis/Jane's Band

Amy Ray as Indigo Girl

Emily Saliers as Indigo Girl

Jude Ciccolella as Jerry

Gedde Watanabe as Steve

Jon Seda as Pete

Mimi Toro as Carrie

Lori Alan as Girl with Attitude

Mary Anne McGarry as Dr. Newbauer

Michael Storm as Tommy

Danielle Shuman as Young Robin

Julian Neil as Nightclub Owner

Niecy Nash-Betts as Woman at Diner

Ted Zurkowski as Drug Buyer

Jill C. Klein as Waitress

Marnie Crossen as Nurse

Aaron Lustig as Judge

Terri White as Female Guard

George Georgiadis as Cab Driver

Cheryl A. Kelly as Hotel Clerk

Adria Contreras as Mary Todd (5 Months)

Malika Edwards as Mary Todd (10 Months)

Pablo Espinosa as New Mexico Police

Kevin La Presle as New Mexico Police

John F. Manfredonia as Obstetrician

James Shuffield as Gynecologist

Thomas Kevin Danaher as Tuscon Police

Richard Lowell McDole as Tuscon Police

Don Hewitt Sr. as Tow Truck Driver

Andy Duppin as Tow Truck Driver

Alan Mirikitani as Jane's Band

Joe Pyles as Jane's Band

Worthy Davis as Jane's Band

Joshua Segal as Indigo Girls' Band

Breta La Von as Indigo Girls' Band

Patrice Jones as Indigo Girls' Band

Tito Larriva as Indigo Girls' Band

Gary Montemer as Indigo Girls' Band

Vernon Francisco as Desert Suns Band

Joseph Alfieri as Bartender (voice)

Fidelis Manuel as Desert Suns Band

Sylvester Oliver as Desert Suns Band

Benedict Martinez as Desert Suns Band