Aaron Eckhart as Nick Naylor

Maria Bello as Polly Bailey

Cameron Bright as Joey Naylor

Adam Brody as Jack

Sam Elliott as Lorne Lutch

Katie Holmes as Heather Holloway

Rob Lowe as Jeff Megall

William H. Macy as Senator Ortolan Finistirre

Robert Duvall as The Captain

David Koechner as Bobby Jay Bliss

J.K. Simmons as BR

Kim Dickens as Jill Naylor

Connie Ray as Pearl

Joan Lunden as Joan Lunden

Mary Jo Smith as Sue Maclean

Todd Louiso as Ron Goode

Jeff Witzke as Kidnapper

Marianne Muellerleile as Teacher

Jordan Garrett as Kid #2

Courtney Taylor Burness as Kid #3

Daniel Travis as Brad

Richard Speight Jr. as Trainee

Renée Graham as Tiffany

Timothy Dowling as EGO Assistant

Dennis Miller as Dennis Miller

Terry James as Ski Mask #1

Marc Scizak as Ski Mask #2

Rachel Thorp as Flighty Girl

Aaron Lustig as Doctor

Melora Hardin as Interviewer

Brian Palermo as FBI Agent (voice)

Michael Mantell as Dr. Meisenbach

Spencer Garrett as Senator Lothridge

Earl Billings as Senator Dupree

Catherine Reitman as Reporter #1

Sean Patrick Murphy as Reporter #2

David O. Sacks as Oil Lobbyist

Nancy O'Dell as Nancy Humphries O'Dell

Roy Jenkins as Debate Moderator

Bruce French as Gentleman #2

Christopher Buckley as Man at Metro Station (uncredited)

Dana E. Glauberman as Hotel Phone Operator (voice) (uncredited)

Eva La Dare as Flight Attendant (uncredited)

Robert Malina as Peter (uncredited)

Aloma Wright as Gizelle (voice) (uncredited)

Elon Musk as Valet (uncredited)