Teyonah Parris as Lysistrata

Nick Cannon as Demetrius 'Chi-Raq' Dupree

Wesley Snipes as Sean 'Cyclops' Andrews

Angela Bassett as Miss Helen Worthy

Samuel L. Jackson as Dolmedes

John Cusack as Fr. Mike Corridan

Jennifer Hudson as Irene

David Patrick Kelly as General King Kong

D. B. Sweeney as Mayor McCloud

Dave Chappelle as Morris

Steve Harris as Ole Duke

Harry Lennix as Commissioner Blades

Anya Engel-Adams as Rasheeda

Ebony Joy as Marcy

Erin Allen Kane as Tee-Tee

Michelle Mitchenor as Indigo

La La Anthony as Hecuba

Val Warner as Electra Johnson

Sarunas J. Jackson as Big Mike

Corey Hendrix as Jah

William Gines as Armonty

Quincy Griffin as Cairo

Chantley Lorraine Ward as Candy

M.J. Carey as Sergeant Toney

Samuel Robinson as Private Alto

Anthony Fitzpatrick as Chief Riptide

Jackie Taylor as Olympia

Gina Breedlove as Althea

Anthony Chisholm as Mr. Doctor Aesop

Darren Jones as Pindar

George Willborn as Tereus

Lamar Greer as Ajani

Wade Forrest Wilson as Oedipus

Erica Faye Watson as Sugar Pie

Latisha Hyman as Big Thelma

Isiah Whitlock, Jr. as Bacchos

Vic Mensa as T-Money

Natasha Forouzannia as Michelle

Duane Sharp as Joe the Supervisor

Sammy Joe Temple as Pretty Pink

Emily Boakye Agyemang as Fifi

Lena Owens as Divine

Eric Wilkins as Spinna

T'Keyah Crystal Keymáh as Lorde

Yaneisha Franklin as Kenya

Tiffany Laos as Lucy

Dusan Sanford as Blue Monday

Al Palagonia as Private Wilbur

Willie Middleton as Tiny Tony

Celeste M Cooper as Barbara

Ilfenesh Hadera as Chifon

Rinska Carrasco as Dancer

Patricia Urbonas Clark as Secretary to Mayor McCloud

Michelle Shelton Huff as Channel 7 News Reporter

John Westford Jr. as J Dog Englewood

Eric Ian as Grey

Alex Zelenka as Chicago Cop

Brandon Bowens as Police Officer

Muhammad Sanders as Cafe Waiter

Curtis Gordon as Chicago Cop

Epic Scon as National Guard Singer / Dancer

Michael Czerniawski as Police officer

Jay Washington as Besomighty

Jermaine Mctizic as National Guard

Aj Brander as Chicago police officer

Kevin Tillett as National Guardsman

Matthew Salter as Riot Police Officer / Bartender (uncredited)

Hans Dieter Wolff as Police riot squad (uncredited)

Thomas Jefferson Byrd as Apollo

Roger Guenveur Smith as Red, White, and Blue Insurance Salesman

Snoop as Dania