Morgan Freeman as Det. Alex Cross

Ashley Judd as Dr. Kate McTiernan

Cary Elwes as Det. Nick Ruskin

Alex McArthur as Det. Davey Sikes

Tony Goldwyn as Dr. Will Rudolph

Jay O. Sanders as FBI Agent Kyle Craig

Bill Nunn as Det. John Sampson, LAPD

Brian Cox as Chief Hatfield, Durham PD

Richard T. Jones as Seth Samuel

Roma Maffia as Dr. Ruocco

Jeremy Piven as Det. Henry Castillo, LAPD

Gina Ravera as Naomi Cross

William Converse-Roberts as Dr. Wick Sachs

Helen Martin as Nana Cross

Tatyana Ali as Janell Cross

Mena Suvari as Coty Pierce

Heidi Schanz as Megan Murphy

Rick Warner as Sgt. Willard

Billy Blanks as Instructor

Dianna Miranda as Jennifer

Mary Major as TV Reporter

Melinda Renna as TV Reporter

Angel Harper as Reporter

Alan Wilder as Reporter

Dan Cashman as Reporter

Patrick Thomas O'Brien as Reporter

Brenda Kincaid as Reporter

Lonnie McCullough as Reporter

Larry Cedar as Reporter

Tresha Rodriguez as Reporter

Caroline Case as Reporter

Loanne Bishop as Kate's Nurse

Tim Ahern as LAPD Sergeant

W. Earl Brown as Locksmith

Brian Brophy as Swim Team Manager

Michael Cutt as FBI Agent (Hospital)

Meta Golding as Beautiful Girl

Sadie Stratton as Beautiful Girl

Brandi Andres as Beautiful Girl

Dana Seltzer as Beautiful Girl

Justina Vail Evans as Beautiful Girl

Nichole McAuley as Beautiful Girl

Tricia Vessey as Woman at Nepenthe Bar

John Cothran as FBI Agent at Lair

Robert Peters as Agent on Robe

Jill Callahan as Female Reporter in Durham

Nancy Yee as Chinese Grandmother

Christina Ma as Chinese Mother

David Cowgill as Chief Resident

Weston Blakesley as Bellman

Joe Inscoe as Large Cop

Deborah Strang as Dianne Wainford

Robert Overmyer as Competitive Swimmer

Boise Holmes as Basketball Player

Anna Maria Horsford as Vicki Cross (uncredited)

Tony Donno as Ethan, Kickboxer (uncredited)

Tracey Walter as Clerk in Bookstore (uncredited)

Gregg Henry as Detective (uncredited)

Anthony Backman as Competitive Swimmer (uncredited)

Jack Kyle as Competitive Swimmer (uncredited)

Lino Marrero as Basketball Player (uncredited)