Denzel Washington as Lincoln Rhyme

Angelina Jolie as Amelia Donaghy

Queen Latifah as Thelma

Michael Rooker as Captain Howard Cheney

Michael McGlone as Detective Kenny Solomon

Luis Guzmán as Eddie Ortiz

Leland Orser as Richard Thompson

John Benjamin Hickey as Dr. Barry Lehman

Bobby Cannavale as Steve, Amelia's Boyfriend

Ed O'Neill as Detective Paulie Sellitto

Richard Zeman as Lieutenant Carl Hanson

Olivia Birkelund as Lindsay Rubin

Gary Swanson as Alan Rubin

James Bulleit as Train Engineer

Frank Fontaine as Grandfather

Zena Grey as Granddaughter

Daniel Brochu as NYU Student

Desmond Campbell as Taxi Inspector

Christian Veliz as Young Boy

Mercedes Gómez as Ortiz's Mother

Mary C. Hammett as Girlfriend in Nightclub

Amanda Gay as Girl in Nightclub

Steve Adams as Gas Worker

Larry Day as Gas Worker

Burke Lawrence as Police Instructor

Terry Simpson as Cop in Apartment

Eric Davis as Cop in Apartment

Arthur Holden as Bookstore Clerk

Yahsmin Daviault as Rhyme's Sister

Keenan MacWilliam as Rhyme's Niece

David Warshofsky as Amelia's Partner

Mateo Gómez as Hot Dog Vendor

Ted Whittall as Ortiz's Assistant

Peter Michael Dillon as Homicide Detective

Jonathan Stark as Male Detective

Fulvio Cecere as Forensics Expert

Hal Sherman as Fingerprint Cop

Russell Yuen as Forensics Worker

Andy Bradshaw as Uniform Cop

Jean-Marc Bisson as Rescue Worker

Christopher Bregman as Rescue Worker

Sonya Biddle as Nurse

Phillip Noyce as Customer in Antique Bookshop (uncredited)

Charles Alonso as News Reporter (uncredited)

Michael Arthur as NYPD Officer (uncredited)

Alex Lorre as Rescue Worker (uncredited)

Todo Segalla as Cop (uncredited)

Andrew Semple as Perp (uncredited)