Denzel Washington as Lincoln Rhyme

Angelina Jolie as Amelia Donaghy

Michael Rooker as Captain Howard Cheney

Michael McGlone as Detective Kenny Solomon

Luis Guzmán as Eddie Ortiz

Queen Latifah as Thelma

Leland Orser as Richard Thompson

John Benjamin Hickey as Dr. Barry Lehman

Bobby Cannavale as Steve, Amelia's Boyfriend

Ed O'Neill as Detective Paulie Sellitto

Richard Zeman as Lieutenant Carl Hanson

Olivia Birkelund as Lindsay Rubin

Gary Swanson as Alan Rubin

James Bulleit as Train Engineer

Frank Fontaine as Grandfather

Zena Grey as Granddaughter

Desmond Campbell as Taxi Inspector

Peter Michael Dillon as Homicide Detective

Ted Whittall as Ortiz's Assistant

Andy Bradshaw as Uniform Cop

Steve Adams as Gas Worker

Christian Veliz as Young Boy

Mercedes Gómez as Ortiz's Mother

Mary C. Hammett as Girlfriend in Nightclub

Amanda Gay as Girl in Nightclub

Larry Day as Gas Worker

Burke Lawrence as Police Instructor

Terry Simpson as Cop in Apartment

Eric Davis as Cop in Apartment

Arthur Holden as Bookstore Clerk

Yahsmin Daviault as Rhyme's Sister

Keenan MacWilliam as Rhyme's Niece

David Warshofsky as Amelia's Partner

Mateo Gómez as Hot Dog Vendor

Jonathan Stark as Male Detective

Fulvio Cecere as Forensics Expert

Hal Sherman as Fingerprint Cop

Russell Yuen as Forensics Worker

Jean-Marc Bisson as Rescue Worker

Christopher Bregman as Rescue Worker

Sonya Biddle as Nurse