Cameron Diaz as Natalie Cook

Drew Barrymore as Dylan Sanders

Lucy Liu as Alex Munday

Demi Moore as Madison Lee

Bernie Mac as Jimmy Bosley

Justin Theroux as Seamus O'Grady

Robert Patrick as Ray Carter

Crispin Glover as Thin Man

Shia LaBeouf as Max Petroni

Luke Wilson as Pete Kominsky

Matt LeBlanc as Jason Gibbons

John Cleese as Mr. Munday

John Forsythe as Charles 'Charlie' Townsend (voice)

Rodrigo Santoro as Randy Emmers

Robert Forster as Roger Wixon

Ja'net DuBois as Momma Bosley

Yuen Cheung-Yan as Deranged Mongol

Daxing Zhang as Demented Mongol

Bruce Comtois as Large Mongol

Khin-Kyaw Maung as Crooked-Tooth

Tanoai Reed as Wrestler

Andrew Wilson as Cop

Eric Bogosian as Alan Caulfield

Eve as Self

Pink as Coal Bowl Starter

Carrie Fisher as Mother Superior

Zack Shada as Thin Boy

Jennifer Gimenez as Nun

Kate Hendrickson as Nun

Josh Janowicz as Hot Priest

Tommy Flanagan as Irish Henchman

Chris Pontius as Irish Henchman

Luke Massy as Irish Henchman

Big Boy as Bosley's Cousin

Anthony Griffith as Bosley's Cousin

Wayne Federman as Bathroom Guy

Steve Hytner as Bathroom Guy

Bob Stephenson as Crazed Fan

Shanti Lowry as Treasure Chest Dancer

Nadine Ellis as Treasure Chest Dancer

Cyia Batten as Treasure Chest Dancer

Staci B. Flood as Treasure Chest Dancer

Carmit Bachar as Treasure Chest Dancer

Béla Károlyi as Self

Ricky Carmichael as Self

Carey Hart as Self

Chris Gosselaar as Self

Jeremy McGrath as Self

Mark Cotone as Prison Guard

Melissa McCarthy as Bystander (uncredited)

Ashley Olsen as Future Angel (uncredited)

Mary-Kate Olsen as Future Angel (uncredited)

Jaclyn Smith as Kelly Garrett (uncredited)

Bruce Willis as William Rose Bailey (uncredited)

Sven-Ole Thorsen as Machine Gun Mongol (uncredited)

Joan Blair as Beach Lady With Sandcastle (uncredited)

Khristian Lupo as Mongolian Key Keeper (uncredited)

Matt McColm as O'Grady's Goon (uncredited)