Denzel Washington as John Quincy Archibald

James Woods as Dr. Raymond Turner

Kimberly Elise as Denise Archibald

Robert Duvall as Lt. Frank Grimes

Shawn Hatosy as Mitch Quigley

Eddie Griffin as Lester Matthews

Kevin Connolly as Steve Maguire

Ethan Suplee as Guard Max Conlin

Ray Liotta as Chief Gus Monroe

Anne Heche as Rebecca Payne

Laura Harring as Gina Palumbo

Heather Wahlquist as Julie Bird

Daniel E. Smith as Mike Archibald

David Thornton as Jimmy Palumbo

Paul Johansson as Tuck Lampley

Obba Babatundé as Sgt. Moody

Troy Byer as Miriam Smith

Troy Winbush as Steve Smith

Martha Chaves as Rosa Gonzales

Gabriela Oltean as Beautiful BMW Driver

Ron Annabelle as Tow Truck Driver

Barry G. King as Employee Manager

Larissa Laskin as Dr. Ellen Klein

Vanessa Branch as Registered Nurse

Stephanie Moore as Admitting Nurse

James Finnerty as Nurse Reggie

Michael Jaye as Insurance Rep

Yanna McIntosh as State Employee

Linda Massad as Social Services Rep

Lester Mathews as Human Services Rep

Noam Jenkins as Medicaid Official

Allegra Fulton as Sick Girl's Mother

Darrin Brown as TV Buyer

Shera Danese as Wife of Heart Transplant Patient

Kirsta Teague as Dr. Turner's Assistant

Rick Sood as Panicked E.R. Doctor

Scott Bloom as Desk Guard

Dina Spybey-Waters as Debby Utley

Carlos Diaz as Paramedic #1

Joe Duer as Paramedic #2

Simon Sinn as Fong

Jeff Douglas as Computer Cop

Keram Malicki-Sánchez as Freddy B.

Philip Williams as Wally Pitoniak

Nigel Shawn Williams as News Anchor

Frank Cassavetes as Sniper

Colin Evans as Videographer

Angelo Tsarouchas as Barricade Cop

Marcia Johnson as Medical Transplant #1

Vijay Mehta as Medical Transplant #2

Andrew Schaff as U.N.O.S. Official

Malcolm Nefsky as Nick

Jay Leno as Jay Leno

Gloria Allred as Gloria Allred

Larry King as Larry King

Arianna Huffington as Arianna Huffington

Ted Demme as Ted Demme

Nas as Nas

Bill Maher as Bill Maher

Claire Rankin as Public Defender

Philip Craig as Judge K. Ploucha

Gerry Quigley as Jury Foreman