Pauly Shore as Bud Macintosh

Stephen Baldwin as Doyle Johnson

William Atherton as Dr. Noah Faulkner

Joey Lauren Adams as Monique

Teresa Hill as Jen

Henry Gibson as William Leaky

Kevin West as T.C. Romulus

Denise Dowse as Olivia Biggs

Dara Tomanovich as Mimi Simkins

Rose McGowan as Denise

Taylor Negron as Russell

Patricia Hearst as Doyle's Mother

Jeremy Jordan as Trent

Trevor St. John as Parker

Channon Roe as Roach

Kylie Minogue as Dr. Petra von Kant

Kyle Gass as Tenacious D

Jack Black as Tenacious D

Christopher Dye as Partier

Loomis Fall as Drummer

Robbie Thibaut Jr. as Young Doyle

Adam Weisman as Young Bud

Brian Hayes Currie as Guard

Butch McCain as Reporter Joachim West

Roger Clinton, Jr. as Prof. Bloom

Mark Burton as Guy

Joe Sib as Singer

Soda Pop as Guitarist

Rene L. Moreno as Partier

Molly Bryant as Bio-Dome Technician

Ben McCain as Anchor Aries West

Katherine Kousi as Vigilante

Elizabeth Guber as Vigilante

Tucker Smallwood as Cmdr. Gates, SWAT Team

Phil LaMarr as Assistant

Paul Eiding as Assistant

Rodger Bumpass as Narrator

Phil Proctor as Axl

Cecile Krevoy as Woman in Bandstand