Jake Gyllenhaal as Jimmy Livingston

Swoosie Kurtz as Mrs. Livingston

Marley Shelton as Chloe

Danny Trejo as Slim

John Carroll Lynch as Mr. Livingston

Verne Troyer as Dr. Phreak

Dave Sheridan as Mark

Brian George as Pushpop

Patrick Cranshaw as Pappy / Pippy

Stephen Spinella as Chicken Man

Ever Carradine as Lisa, Mark's Sister

Geoffrey Arend as Flipper Boy

Beetlejuice as Li'l Zip

Matthew McGrory as Human Sasquatch

Bonnie Morgan as Rubber Woman

Jason Sklar as Shlomo

Randy Sklar as Dawn

Ping Wu as Emcee

Zach Galifianakis as Bus Stop Man

Boti Bliss as Cashier

Pablo Schreiber as Todd

Brian Gattas as Todd

Cinco Paul as Todd

Ken Daurio as Todd

Malik Toure as Todd

Leo Fitzpatrick as Todd

J.P. Coe as Todd

R.J. Durell as Todd

Brian Friedman as Todd

Arden Myrin as Lorraine

Merle Kennedy as Lorraine

Shulie Cowen as Lorraine

Alicia Gilley as Lorraine

Mandy Moore as Lorraine

Mitch Holleman as Jimmy, 4 Years Old

Alex Black as Jimmy, 8 Years Old

Tony Black as Jimmy, 10 Years Old

Robert Bailey Jr. as Neighborhood Boy

Oliver Kindred as Neighborhood Boy

Brandon de Paul as Neighborhood Boy

Steve Van Wormer as Mark's Friend

E.J. Callahan as Perris Townie

Charlie Dell as Perris Townie

Michael Loprete as Perris Townie

Charles Noland as Perris Townie

Emily Stewart as Perris Townie

Pattie Tierce as Perris Townie

Gary Bullock as Perris Sheriff

Susan Hawk as Perris Waitress

Steven Anthony Lawrence as Ice Cream Boy

Raja Fenske as Indian Boy

Cleo King as Minister

Robert LaSardo as Skinny Biker

Jorge Cottini as Big Biker

Mindie McCullum as Red Hot

Stacy Keibler as Working Girl

Fabio as Gil

Cyia Batten as Dancer (uncredited)

Bianca Butthole as Member of 'Betty Blowtorch' (uncredited)

Charles M. Kerper as Cult Member (uncredited)

Katie Lohmann as Cult Member (uncredited)

Daniel Mandehr as Casino Guy (uncredited)

Michael A. Tessiero as Fan in Leather Pants (uncredited)

Cal Thomas as Cult Member (uncredited)

Jenna Z. Wilson as Cult Member (uncredited)