Misha Collins as Paul Bernardo

Laura Prepon as Karla Homolka

Brandon Routh as Tim

Patrick Bauchau as Dr. Arnold

Emilie Jacobs as Debbie

Adam Lieberman as Detective Morgan

Shawn Hoffman as Detective Steve Kirby

William Duffy as Detective Porter

Alex Boyd as Nick

Cherilyn Hayres as Tammy Homolka

Kristen Honey as Tina McCarthy (as Kristen Swieconek)

Cole James as Tina's Friend

Carole Ita White as Waitress

Fiona Manners as Rape Victim #1

Tanya Lemelle as Rape Victim #2

Tony Shawkat as Border Guard #1

Tess Harper as Molly

Leonard Kelly-Young as Dan

Anna Pheil as Patricia

Zach DiLiberto as Doug

Nikki McCauley as Jessie

Sarah Foret as Kaitlyn Ross

Tony Denison as Detective Burroughs

Jeff Doucette as Burroughs's Partner

Bunny Gibson as Mrs. Ross

Bradford English as Mr. Ross

John Ross Clark as Attorney Warner

Philippe Bergeron as Attorney Siegel

Eileen Dietz as Helen

Ross Patterson as Steve