Michael Keaton as John Knox

Al Pacino as Xavier Crane

Marcia Gay Harden as Ruby Knox

James Marsden as Miles Knox

Suzy Nakamura as Detective Emily Ikari

Joanna Kulig as Annie

Ray McKinnon as Thomas Muncie

John Hoogenakker as Detective Rale

Lela Loren as Cheryl Knox

Morgan Bastin as Kaylee Knox

Dennis Dugan as Philo Jones

Jay Paulson as Detective Gelfuso

Sasha Neboga as Ludmilla

Marisa Echeverria as Bianca Delgado

Chad Donella as Jordan Moore

Nicole Reddinger as Annette Elmore

Chad Chambers as Orderly

Paul Perri as Dr. Burns

Edwin Garcia II as Elian Zubiri

Kristofer Gordon as Storage Clerk

Martin Garcia as Daniel Warren

Rena Bobbs as Nicole Richardson

Gugun Deep Singh as John Bustamonte

Natasha Galano as Margaret Pierce

Charles Bisset as Andrew Palmer

Jimmy Ortega as Guard

Benita Krista Nall as CSI Tech

Roberto Portales as Uniformed Cop

Alison Acosta as Uniformed Officer

Adrian Gaeta as Uniformed Officer #2

James Croak as Man #1

Joshua Mabie as Man #2

Rob Mars as Man #3

Anthony Molinari as Adult Man

Zedric Harris as County Jail Guard

Skip Howland as Diner Patron w Tattoos (uncredited)