Cristiana Dell'Anna as Francesca Cabrini

David Morse as Archbishop Corrigan

Giancarlo Giannini as Pope Leo XIII

John Lithgow as Mayor Gould

Romana Maggiora Vergano as Vittoria

Federico Ielapi as Paolo

Virginia Bocelli as Aria

Rolando Villazón as Disalvo

Jeremy Bobb as Calloway

Federico Castelluccio as Senator Bodio

Patch Darragh as Dr. Murphy

Seán Cullen as Peterson

Andrew Polk as Deputy Mayor Jenkins

Allen Lewis Rickman as Jacob Abrams

Giampiero Judica as Father Morelli

Kevin Tanski as Officer Rentschler

Fausto Russo Alesi as Cardinale

Sam Bond as Mr. Merton

Montserrat Espadalé as Sister Concetta

Peter Lojacono as Vincenzo

Sarah Santizo as Sister Lucille

Brian Ceponis as Cabbie

Eugenia Forteza as Sister Umilia