Ben Affleck as Jack Giamoro

Rebecca Romijn as Nina Giamoro

John Cleese as Dr. Primkin

Mike Binder as Morty

Gina Gershon as Arlene Kreiner

Adam Goldberg as Phil Balow

Howard Hesseman as Ben Giamoro

Jerry O'Connell as David Lilly

Kal Penn as Alan Fineberg

Amber Valletta as Brynn Lilly

Damien Dante Wayans as Lucky Reynolds

Laura Soltis as Barbara Giamoro

Bai Ling as Barbi Ling

Sam Ball as Jimmy Dooley

Erica Cerra as Sela

Anita Brown as Model

Ben Immanuel as Dr. Kevin Sands

Gina Holden as Pretty Young Assistant

Dustin Milligan as Young Dooley

Kathy Tong as Model