Charlize Theron as Jill Young

Bill Paxton as Gregg O'Hara

Rade Šerbedžija as Strasser

Peter Firth as Garth

David Paymer as Harry Ruben

Regina King as Cecily Banks

Robert Wisdom as Kweli

Naveen Andrews as Pindi

Lawrence Pressman as Dr. Baker

Linda Purl as Dr. Ruth Young

Mika Boorem as Young Jill Young

Geoffrey Blake as Vern

Christian Clemenson as Jack

Cory Buck as Jason

Liz Georges as Jason's Mother

Richard Riehle as Commander Gorman

Cynthia Allison as News Reporter

Ken Taylor as News Reporter

Ray Harryhausen as Gentleman at Party

Terry Moore as Elegant Woman at Party

Judson Mills as Impatient Driver

Tony Genaro as Boxer Shorts Man

Flo Di Re as Bambi's Owner

Kaylan Romero as Street Kid

Hernan Ruiz as Street Kid

Jenilee Deal as Street Kid

Matt Deal as Street Kid

Bethany Bassler as Cabriolet Girl

Vicki Davis as Cabriolet Girl

Deborah Kellner as Cabriolet Girl

Marguerite Moreau as Cabriolet Girl

Tracey Walter as Conservacy Guard

Larry Brandenburg as Animal Control Duty Officer

Damien Leake as Cop

Neil Kopit as Cop

Janet Eilber as Concerned Mother

Wiley M. Pickett as Police Sharpshooter

John Bower as Carjack Man

Hannah Swanson as Toddler

Laurie Kilpatrick as Toddler's Mom

Richard McGonagle as Panda Owner

Reno Wilson as Poacher

Ted Hartley as Society Man

Dina Merrill as Society Woman

Lily Mariye as Ticket Clerk

John Alexander as Mighty Joe Young

Verne Troyer as Baby Joe

John Munro Cameron as Joe's Mother Gorilla

David St. Pierre as Joe's Father Gorilla

Debbie Lee Carrington as Other Gorilla

Denise Cheshire as Other Gorilla

Darren T. Knaus as Baby Joe (voice)